IRCT20090613002027N16 IRCT 2019-09-17 Mazandaran University of Medical Sciences effect of amlodipine on oxidative stress markers and serum ferritin level in β-thalassemia patients Evaluation of the effect of amlodipine on oxidative stress markers and serum ferritin level in β-thalassemia patients undergoing iron chelation therapy: A randomized double-blind Cross-Over study 2019-01-09 anticipated 62 Complete https://irct.ir/trial/33008 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Crossover, Purpose: Treatment, Randomization description: Stratified randomization will be performed for patients based on MRI before enrollment in the study [MRI T2 of 10 to 15 milliseconds (moderate iron deposition in the heart) and MRI T2 of less than 10 milliseconds (severe iron deposition in the heart). ٌWhether the patient receives first Amlodipine then Placebo or first Placebo then Amlodipine will be determined by block randomization, Blinding description: A separate 5-digit code obtained from the computer will be assigned to each patient.The intervention, including the drug or placebo, will be placed in identical containers, and the senior researcher will insert the code on the containers. The researcher and patient will not be aware of the type of intervention received. 2 β-thalassemia. Intervention 1: Intervention group: amlodipine tablets 5 mg daily for 6 months. Intervention 2: Control group: Amlodipine placebo daily for 6 months. No - There is not a plan to make this available Justification or reason for not sharing IPD is Due to confidentiality of patients data