IRCT20100209003320N15 IRCT 2018-08-02 Tabriz University of Medical Sciences Effects of prebiotic supplementation and calorie restriction in major depressive disorder The effects of a weight loss diet with or without prebiotic supplementation on anthropometric measures, metabolic and inflammatory status, gut permeability, endotoxemia and depression status in obese women with major depression disorder 2018-06-22 anticipated 48 Complete https://irct.ir/trial/32972 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: From among the patients who volunteer to participate in the study, 48 individuals will be selected by simple randomization. Then by using the Random Allocation Software, the subjects will be allocated into either prebiotic or placebo group, stratified by depression severity and BMI, Blinding description: In this study, the main investigators (including the student, and her supervisor and adviser professors) as well as the patients will be blinded to the type of the supplement (prebiotic or placebo) received by each group. The person responsible for preparing the supplement sachets (who is completely unrelated to the study) will be asked to assign a three digit code to each of the two powders (prebiotic and placebo), and keep the codes for himself until the end of the study and data analyses. N/A Condition 1: Major depressive disorder, mild. Condition 2: Major depressive disorder, moderate. Intervention 1: Intervention group: Patients in this group will receive weight loss diet and prebiotic supplements for 8 weeks. Prebiotic supplement is a sachet containing 10 grams of inulin (a product by Sensus Co.and made in The Netherlands) which will be dissolved in a glass of water and used once a day with lunch. Intervention 2: Control group: Patients in this group will receive weight loss diet and placebo for 8 weeks.Placebo is a sachet containing 10 grams of maltodextrin (a product by FIC Co. and made in China)which will be dissolved in a glass of water and used once a day with lunch. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information