IRCT20180724040575N3 IRCT 2020-09-29 Shahid Beheshti University of Medical Sciences Effect of tranexamic acid on coronary perfusion Comparison of different doses of tranexamic acid on coronary perfusion in patients undergoing coronary artery bypass graft surgery (CABG) 2018-08-23 anticipated 120 Complete https://irct.ir/trial/32930 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: All patients who go to the cardiac operating room from the beginning of sampling and meet the necessary criteria are included in the study. For assignment in intervention and control groups, simple randomization method is used with the help of random numbers(RAND) in Excel software. In cell A1, type the formula = RAND () * (120-1) +1. By confirming and dragging to A60, we have sixty random numbers between 1 and 120. These numbers are the rows of participants in the intervention group(high dose tranexamic acid). For each row of participants, a closed envelope is prepared by the researcher not present in the operating room, and with the arrival of each patient, the relevant envelope is opened by the project partner in the operating room and the designated group is determined, Blinding description: Consent for participation in the study is obtained from all patients, but the participants and data collector are blind about the study groups. The researcher and patient care team are aware of the groups. 3 Coronary artery bypass graft surgery. Intervention 1: Intervention group: Patients undergoing coronary artery bypass graft receiving a high dose of tranexamic acid. In this group, after induction of anesthesia, tranexamic acid drug made by Caspian Pharmaceutical Company (500 mg vial in 5 ml) at a dose of 25 mg / kg body weight by slow intravenous injection as a loading dose and then 5 mg / kg body weight It is given as an intravenous infusion as a maintenance dose until the end of the operation. Intravenous infusion is performed with the help of a pump syringe and the drug dissolved in a 50 ml syringe. Intervention 2: Control group: Patients undergoing coronary artery bypass graft receiving a standard dose of tranexamic acid. In this group, after induction of anesthesia, tranexamic acid drug made by Caspian Pharmaceutical Company (500 mg in 5 ml) at a dose of 10 mg / kg body weight by slow intravenous injection as a loading dose and then 2 mg / kg body weight It is given as an intravenous infusion as a maintenance dose until the end of the operation. Intravenous infusion is performed with the help of a pump syringe and the drug dissolved in a 50 ml syringe. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information