IRCT20180619040151N1 IRCT 2018-09-18 Tehran University of Medical Sciences Investigation of the effects of curcumin in patients hospitalized at intensive care unit Investigation of the Effects of Curcumin Supplementation on Inflammatory, Oxidative stress and Adipokine Markers and Nutritional and Clinical status in Traumatic Brain Injury Patients Receiving Enteral Nutrition at Intensive Care Unit 2018-11-02 anticipated 52 Complete https://irct.ir/trial/32922 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: In this study, stratified randomization will be used. First, the participants will be stratified based on age (18-40 or 40-65 years old) ,sex (male or female) and APACHEII score (0-35 or 35-71) and then they will be allocated to intervention or placebo group based on the blocks of size 4. Blocks of size 4 have 6 modes (AABB، ABAB، ABBA، BBAA، BAAB، BABA). These modes will be available to the relevant nurse and based on these blocks, the patients will be placed in the intervention or placebo group, Blinding description: The supplements (curcumin or placebo) used in this study are exactly similar in appearance. Moreover, neither researcher nor patients or their first degree relatives will not know the kind of supplements and supplements will be administered by the relevant nurse. 3 Traumatic Brain Injury. Intervention 1: Intervention group: This group will receive 500 mg curcuminoids in combination with 5 mg piperine (produced by Sabinsa company) added to enteral nutrition formula for 7 days. Because of low bio availability of curcuminoids, piperine will be added to increase it. Intervention 2: Control group: This group will receive matched placebo (lactose) added to enteral nutrition formula for 7 days. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information.