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IRCT20180417039338N3 IRCT 2019-01-26 Babol University of Medical Sciences Nifedipine on Pregnancy Rates in ICSI cycles Effect of Nifedipine Administration Before Embryo Transfer on Pregnancy Rates in ICSI cycles, a double blind control trial study 2018-03-21 anticipated 100 Complete https://irct.ir/trial/32902 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: The medicine contains 100 pills of nifedipine 10 mg (Tolidaru co.) from the package and both are placed in a uni-shape capsule by data collector. As well as 100 pills of folic acid (Iran Drug Pharmacy), 1mg will also be placed in uni-color capsules. The capsules are then inserted into a small uni-shape zipped bag and placed in the uni- shape pocket according to the code. Then the code list will extinct, Randomization description: All blocking and random allocation processes are performed by the University's statistics center. The statistician uses the online randomization method and the online Randomization.com site for random block assignment. Ultimately, patients are assigned through methods in two groups according to randomized block-sized numbers with block-8, Blinding description: According to the randomized block list, which is given to the mentioned midwife from the university's statistics center, the prescription of the encoded uni- shape pills is done by her. In the end, the list of demographic characteristics and pregnancy outcomes are collected and recorded by the outcome assessor. Patients, the endometrial monitor responsible, the embryo transfer physician, the ICSI laboratory staff and the outcome assessor are not aware of the patient's allocation. The list is inserted in SPSS by statistics. 3 Recurrent Implantation failure in IVF. Intervention group: Intervention group are received Nifedipine Tablet 20 mg for 1/2 hr before embryo transfer. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Fatemeh
Babol- Amol old road
Babol Iran (Islamic Republic of) 47135-547 +98 11 3227 4882 m.golsorkhtabar@gmail.com Babol University of Medical Sciences scientific Zahra
Babol- Amol old road
Babol Iran (Islamic Republic of) 47135-547 +98 11 3227 4882 basiratzahra@yahoo.com Babol University of Medical Sciences Iran (Islamic Republic of) 1.Women 18-40 yr with BMI<38 undergo ICSI treatment and freeze embryo transfer candidate are participated in this study.2. Blood pressure >= 100/60, 3. FSH <14mli/IU. 4. abnormal uterus in HSG or hystroscopy. 5. who do not contraindicate the use of nifedipine, such as heart and liver 6. Patients who do not have a history of irregular heart rate or who do not use hypotention medication. 18 years 40 years Female Patients who have been taking medication with nifedipine over a month have interfered with drugs such as benzodiazepines, flecainide, imipramine, propafenone, azole antifungals, cimetidine, cyclosporine, erythromycin, quinidine, terfenadine, warfarin and theophylline. 2.Those who have blood pressure of 60/100 (mmHg) or less before embryo transfer Treatment - Drugs Intervention group: Intervention group are received Nifedipine Tablet 20 mg for 1/2 hr before embryo transfer Pregnancy rate( hCG>31IU/LI) 12 days following embryo transfer. Timepoint: 12 days following embryo transfer. Method of measurement: Blood test, BHCG. Implantation rate: Gestational sac. Timepoint: in 6 weeks after pregnancy. Method of measurement: vaginal sonography. Clinical pregnancy, Fetal heart rate observation. Timepoint: 6-8 after pregnancy. Method of measurement: vaginal sonography. Spontaneous abortion. Timepoint: before 20 week pregnancy. Method of measurement: vaginal sonography. Complications of pregnancy and infant including multiple or ectopic pregnancy, spotting and vaginal bleeding. Timepoint: in 3 months pregnancy. Method of measurement: vaginal sonography. Babol University of Medical Sciences Approved 2018-08-01 BaboL university of Medical Science Ghanj afrouz ST. Babol Mazandaran Iran (Islamic Republic of)