]>
IRCT20180613040087N1 IRCT 2018-08-01 Shiraz University of Medical Sciences Treatment of Organophosphate poisoning with Pralidoxime Comparison of continuous infusion versus intermittent bolus injection of Pralidoxime for the treatment of Organophosphate poisoning 2018-07-23 anticipated 80 Complete https://irct.ir/trial/32690 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization will be performed by using a randomization table based on the registration number of the patients, Blinding description: Just patients will be blinded to the intervention allocation. 3 Organophosphate poisoning. Intervention 1: Intervention group: Continuous infusion of 8g pralidoxime in 24 hours. Intervention 2: Intervention group: Bolus injection of 1-2g pralidoxime in 20 minutes, then will be repeated every 6 hours. Yes - There is a plan to make this available What will be shared: All data related to the patients will be shared after identifying the patients. When: Starting 1 month after publication To whom: This only available for people working in academic institutions Conditions: All statistical analysis are allowed in line with the objectives of the study. Application terms for access to data including: People working in academic institutions who have registered a protocol liked our study. People are committed to data protection. Where to obtain: Azadeh Tafakori, Shiraz Nemazee Hospital, Email: dr.azadeh.tafakori@gmail.com How to obtain: Through automation correspondence or email Comments:
public Zahra Hasani
Department of Emergency Medicine, Nemazee Hospital, Zand Ave
Shiraz Iran (Islamic Republic of) 71348-45794 +98 71 3647 4332 hasaniz@sums.ac.ir Shiraz University of Medical Sciences scientific Azadeh Tafakori
Department of Emergency Medicine, Nemazee Hospital, Zand Ave
Shiraz Iran (Islamic Republic of) 71937-11351 +98 71 3647 4332 dr.azadeh.tafakori@gmail.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Patients with Organophosphate poisoning admitted to the emergency department of Ali-Asghar Hospital 18 years 80 years Both Patients with age less than 18 or more than 80 years old Patients who are poisoned with Carbamate compounds Patients who have received treatment prior to arriving at our center Patients with history of history of lung diseases T60.0 Toxic effect of organophosphate and carbamate insecticides Treatment - Drugs Treatment - Drugs Intervention group: Continuous infusion of 8g pralidoxime in 24 hours Intervention group: Bolus injection of 1-2g pralidoxime in 20 minutes, then will be repeated every 6 hours Duration of Atropine therapy. Timepoint: From admission to hospital discharge. Method of measurement: Based on day. Duration of ICU stay. Timepoint: From admission to hospital discharge. Method of measurement: Based on day. Mortality rate. Timepoint: From admission to hospital discharge. Method of measurement: Census. Shiraz University of Medical Sciences Approved 2018-06-18 Ethics Committee of Shiraz University of Medical Sciences Headquarters Of Shiraz University of Medical Sciences, Zand St, Shiraz Shiraz Fars Iran (Islamic Republic of)