IRCT20180623040209N1 IRCT 2018-08-04 Shiraz University of Medical Sciences Prolotherapy in Knee Osteoarthritis Comparison of the Effectiveness of Intra-articular Prolotherapy versus Peri-articular Prolotherapy on Pain Reduction and Function Improvement in Patients with Knee Osteoarthritis with Effusion 2018-08-06 anticipated 60 Complete https://irct.ir/trial/32477 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be randomly allocate in two groups using random number table and will adjust by age and sex, Blinding description: Participants will randomly allocate into two groups using random number table, while the researcher is blind about the groups. Also, patients are blinded about the group which they were allocated. After the applying the treatment, while assessing the outcomes and analyzing data, the interviewer of outcomes and the analyzing team will be blinded about the groups, respectively. N/A Knee Osteoarthritis. Intervention 1: In the first group patients lies on bed, patient’s knee with placing a pillow under it flexes to 30 degrees then practitioner prepare the knee and injects 8 ml of 10% hyper tonic dextrose with 2 ml of 2% Lidocaine will be injected in the joint and the injection will repeat two weaks later. Intervention 2: In the second group patients lies on bed, patient’s knee with placing a pillow under it flexes to 30 degrees then practitioner prepare the knee and 5 ml of 20% hyper tonic dextrose with 5 ml of 1% Lidocaine will be injected in specified points around the joint and the injection will repeat two weaks later. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no future information.