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IRCT20180628040274N1 IRCT 2018-08-24 Zahedan University of Medical Sciences Comparison of analgesic effect of Paracetamol with combination of Paracetamol and Propofol in the relief of acute migraine headache Survey of the analgesic effect of venous Paracetamol in comparison with the combination of venous Paracetamol and Propofol in the relief of acute migraine headache 2018-08-21 anticipated 80 Complete https://irct.ir/trial/32402 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The samples are randomly divided into 8 groups in a randomized block and then will divide into 2 groups. Accordingly, based on the probability of placing the patient in a group of 8 in each block, 4 patients in group A and 4 patients in group B Will be accidental. Then, on a visit, a block is selected and will be assigned to the relevant group based on the order of the patient's arrival and the card row in each patient block, Blinding description: This is double-blind clinical trial study, only the The doctor is responsible for distributing the medication knows the name of the drug and the patient and other physician who registers the pain score is not aware of the type of medication taken. 3 Acute migraine headache. Intervention 1: Intervention group1: Paracetamol recipients - After giving explanations and obtaining the written consent of individuals to participate in the project, this group will receive 1000 mg Paracetamol. Intervention 2: Intervention group2: Receiving Paracetamol and Propofol combination - After giving explanations and obtaining written consent of individuals to participate in the project, this group will receive 500 mg Paracetamol and 0.5 mg / kg Propofol (due to combination of Paracetamol and Propofol, the dose of Paracetamol is reduced to 500 mg). Yes - There is a plan to make this available What will be shared: Only part of the information, such as the main outcome information, can be shared. When: The start of the access period will be 6 months after the publication of the results. To whom: Data will only be available to scholars working in university and academic institutions. Conditions: The data should be used only for the purpose of future studies. Where to obtain: Visit the university vice chancellor for research. How to obtain: The data will be accessible by the university's research director upon confirmation of the application. Comments:
public Farahnaz Ahmadi
Zahedan University of Medical Sciences, Dr Hesabi sq., Daneshgah blvd.
Zahedan Iran (Islamic Republic of) 9816743463 +98 54 3329 5744 farahnaz.ahmadi@zaums.ac.ir Zahedan University of Medical Sciences scientific Farahnaz Ahmadi
Zahedan University of Medical Sciences, Dr Hesabi sq., Daneshgah blvd.
Zahedan Iran (Islamic Republic of) 9816743463 +98 54 3329 5744 farahnaz.ahmadi@zaums.ac.ir Zahedan University of Medical Sciences Iran (Islamic Republic of) Failure to receive narcotic drugs or other Triptans, such as vasoconstrictor, such as Dihydroergotamine, within 24 hours before referral to the emergency department Patients treated with systemic Corticosteroids Patients with Diabetes Mellitus history, active gastrointestinal ulcers, myocardial infarction in the last week Family history of hypocalmic paralysis (for Dexamethasone) no limit no limit Both Those who have kidney failure G43 Migraine Treatment - Drugs Treatment - Drugs Intervention group1: Paracetamol recipients - After giving explanations and obtaining the written consent of individuals to participate in the project, this group will receive 1000 mg Paracetamol. Intervention group2: Receiving Paracetamol and Propofol combination - After giving explanations and obtaining written consent of individuals to participate in the project, this group will receive 500 mg Paracetamol and 0.5 mg / kg Propofol (due to combination of Paracetamol and Propofol, the dose of Paracetamol is reduced to 500 mg). Pain. Timepoint: Pain score is recorded based on the VAS scale before treatment and 5, 10, 20, 30, and 45 minutes after treatment. Method of measurement: By VAS or Visual Analogue Scale. Zahedan University of Medical Sciences Approved 2018-05-22 Ethics committee of Zahedan University of Medical Sciences Zahedan University of Medical Sciences, Dr Hesabi sq., Daneshgah blvd. Zahedan Sistan-va-Balouchestan Iran (Islamic Republic of)