IRCT20120215009014N226 IRCT 2018-07-01 Hamedan University of Medical Sciences Effect of oral N-Acetylcysteine versus placebo on the severity of the clinical signs in patients with acne Effect of oral N-Acetylcysteine versus placebo on the severity of the clinical signs in patients with acne: a double-blind randomized clinical trial 2018-07-06 anticipated 90 Complete https://irct.ir/trial/32029 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random assignment of the patients to the intervention and control groups through the drawing of lots, Blinding description: Patients will be unaware of the type of intervention. The physician who will examine the patients will not be aware of the intervention. Therefore, the trial will be run as double-blind. 2 Acne. Intervention 1: Intervention group: Capsule Doxycycline 100 mg twice a day for 8 weeks and ointment Clindamycin 1% or Benzyl peroxide 5% twice a day for 8 weeks and tablet N-Acetylcysteine 600 mg twice a day for 8 weeks. Intervention 2: Control group: Capsule Doxycycline 100 mg twice a day for 8 weeks and ointment Clindamycin 1% or Benzyl peroxide 5% twice a day for 8 weeks and tablet placebo twice a day for 8 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It depends on the situations and the results of the study as well as approval of the financial supporting organization.