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IRCT20180619040147N1 IRCT 2018-08-20 Iranian academic center for education culture and research Evaluation of the safety and feasibility of infra ovarian injection of menstrual blood derived stem cells (MenSCs) in women with premature ovarian failure Evaluation of the safety and feasibility of infra ovarian injection of menstrual blood derived stem cells (MenSCs) in women with premature ovarian failure 2018-07-11 anticipated 30 Complete https://irct.ir/trial/31979 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 1-2 premature ovarian failure. Intervention 1: Intervention group includes 15 patients with premature ovarian failure that will be treated by stem cell injection. Intervention 2: Control group: includes 15 patients with premature ovarian failure that will not receive any intervention and their biochemical parameters, sonographic and embryologic data will be compared with intervention group. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.
public Somaieh kazemnejad
Avicenna Research Institute for Biological Sciences, Shahid Beheshti University, Shahid Chamran Highway, Tehran, Iran
Tehran Iran (Islamic Republic of) 1936773493 +98 22432020 kazemnejad_s@yahoo.com Iranian academic center for education culture and research scientific Somaieh kazemnejad
Avicenna Research Institute, Shahid Beheshti University, Shahid Chamran Highway, Tehran, Iran
Tehran Iran (Islamic Republic of) 1936773493 +98 21 2243 2020 kazemnejad_s@yahoo.com Iranian academic center for education culture and research Iran (Islamic Republic of) got married woman normal karyotype FSH more than 20 IU/ml anti mullerian hormone; less than 1 ng/ml spermogram: more than 15 million/ml, normal morphology more than 2%, sperm motility (A+B) morethan 25%anteral follicles: less than 5 20 years 40 years Female thyroid dysfunction immune disorders history of cancer, chemotherapy and radiotherapy infected by hepatitis B,C or HIV severe endometriosis history of ovarian surgery diabetes dysfunction of electrolyte or liver tests psychological problem like depression, high stress an anxiety E28.31 Premature menopause Treatment - Other Treatment - Other Intervention group includes 15 patients with premature ovarian failure that will be treated by stem cell injection. Control group: includes 15 patients with premature ovarian failure that will not receive any intervention and their biochemical parameters, sonographic and embryologic data will be compared with intervention group. Number and diameter of anteral follicles, FSH level, AMH level, ovary volume, menstruation. Timepoint: 3 months, 6 months and one year after cell administration. Method of measurement: sonography, embryologic evaluation, biochemical assays. Iranian academic center for education culture and research Approved 2018-05-06 ACECR Biomedical Research Ethics Committee 1270, Secretariat of the Ethics Committee of ACECR,Deputy Director of Research and Technology, Headquarters of ACECR, Opposite the main door of Tehran University, Enghelab Street, Tehran Tehran Tehran Iran (Islamic Republic of)