IRCT20180131038581N2 IRCT 2018-07-05 Bandare-abbas University of Medical Sciences Investigating the effect of Sequential Therapy and Triple Therapy for H-pylori treatment Comparison of the effect of Sequential Therapy and Triple Therapy for Helicobacter Pylori Eradication 2018-06-22 anticipated 144 Complete https://irct.ir/trial/31711 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, patients with gastrointestinal symptoms such as nausea, vomiting, indigestion and melena, who did not respond to experimental therapy and who were candidates for endoscopy, were included in the study. Patients were randomly divided into two groups of sequential therapy and standard triple therapy by tossing a coin, Blinding description: Information about the type of treatment will be kept secret from the patients, pathologists, and physicians involved in the treatment. For this purpose, the drugs of each group will be placed in the same package alongside the instructions and will be given to the patients. 2-3 Helicobacter Pylori. Intervention 1: Intervention group 1: Patients in sequential therapy group received pantoprazole 20 mg twice daily for 10 days, amoxicillin 1000 mg twice daily for the first 5-day period followed by tinidazole 500 mg twice daily for the second 5-day period. Intervention 2: Intervention group 2: Patients in standard triple therapy group, received pantoprazole 20 mg, clarithromycin 500 mg, and amoxicillin 1000 mg (all medicines twice daily) for 14 days. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information.