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IRCT201601113133N8 IRCT 2016-04-18 Vice chancellor for research,Zahedan University of Medical Sciences The effect of lycopene in the treatment of oral lichen planus OLP-oral lichen planus Evaluation of effectiveness of lycopen in improvement of erosive and atrophic oral lichen planus lesions 2015-12-11 anticipated 2 Complete https://irct.ir/trial/3163 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: Study subjects will be divided into 2 groups using quadruple blocks. 3 oral lichen planus. Intervention 1: Intervention group: In this group, patients will receive topical corticosteroid in addition to lycopene, patient will use the drug 4 times a day for 2 weeks (An hour befor each meal and 20 minutes befor sleep), and avoid eating, drinking and smoking for at least an hour after using the drug. One lycopene tab should be taken each day. Intervention 2: control group:In this group, patient will receive just topical corticosteroide and patient will to use the drug 4 times a day for 2 weeks (An hour befor each meal and 20 minutes befor sleep), and avoid eating, drinking and smoking for at least an hour after using the drug.
public Dr. Fateme Arbabi Kalati
Zahedan, eastern Azadagan street, dentistry college
zahedan Iran (Islamic Republic of) +98 54 1244 1824 F kalati@yahoo.com Zahedan University of Medical Sciences scientific Fateme Arbabi-Kalti
Dental school of Zahedan
zahedan Iran (Islamic Republic of) +98 54 1244 1824 F kalati@yahoo.com Zahedan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria:Diagnostic criteria is clinical and histopathological view of the lesions. Exclusion criteria: patients with systemic disease, skin lichen planus, drug user, pregnant wemen, smokers, patients with dysplastic lesions and lesions close to restorations and also patients receiving treatment for oral lesions was than a month ago. no limit no limit Both L43.8 Other lichen planus Treatment - Drugs Placebo Intervention group: In this group, patients will receive topical corticosteroid in addition to lycopene, patient will use the drug 4 times a day for 2 weeks (An hour befor each meal and 20 minutes befor sleep), and avoid eating, drinking and smoking for at least an hour after using the drug. One lycopene tab should be taken each day. control group:In this group, patient will receive just topical corticosteroide and patient will to use the drug 4 times a day for 2 weeks (An hour befor each meal and 20 minutes befor sleep), and avoid eating, drinking and smoking for at least an hour after using the drug. Reduction in size of the lesion. Timepoint: Before starting treatment, every week for 12 weeks after starting treatment. Method of measurement: In each follow up session size of the lesion will be measured by caliper. Reduced pain of the lesion. Timepoint: Before starting treatment, every week for 12 weeks after starting treatment. Method of measurement: Use of Visual Analoge Scale (VAS) from 0- 10, 0: no pain sensation and 10: severe pain sensation. Vice chancellor for research,Zahedan University of Medical Sciences Approved 2015-06-27 Ethics committee of Zahedan University of Medical Sciences Zahedan University of Medical Sciences-Dental school of Zahedan Zahedan Iran (Islamic Republic of)