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IRCT20100119003106N36 IRCT 2018-03-10 Pharmaceutical Sciences branch, Islamic Azad University Assessment of the effect of cholecalciferol ointment on atopic eczema Assessment of the effects of vitamin D3 (cholecalciferol) ointment on atopic eczema in patients 2-18 years old 2017-05-22 anticipated 30 Complete https://irct.ir/trial/3137 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: This study was designed simple randomization method using random numbers table, Blinding description: Patients with vitamin D in excess of 30 ng/ml received ointment and placebo in two-blinded manner. The ointments are coded by the Pharmaceutical Department of the College of Pharmacy (a and b) and the researcher, physicians, and patients do not know the contents of ointment. 3 Atopic dermatitis. Intervention 1: Patients in the control group should use a drug-free ointment once a day for 8 weeks on lesions.The placebo ointment contains 95% vaseline and 5% bee wax. Intervention 2: Patients in the intervention group should use cholecalciferol 1000 unit per gram ointment once a day for 8 weeks on lesions. Undecided - It is not yet known if there will be a plan to make this available
public Rayeheh Tavajjohi
Pharmaceutical Sciences Branch of Islamic Azad University، Yakhchal Avenue، Doctor Shariati Avenue، Tehran
Tehran Iran (Islamic Republic of) 19395-6466 +98 21 2264 0051 rayehetavajohi@yahoo.com Islamic Azad University Of Pharmaceutical Sciences Branch scientific Dr Mehdi Rajabi
Islamic Azad University Of Pharmaceutical Sciences Branch، Yakhchal avenue، Dotor Shariati avenue، Tehran
Tehran Iran (Islamic Republic of) 19395-6466 +98 21 2264 0056 mehdirj@aol.co.uk Islamic Azad University Of Pharmaceutical Sciences Branch Iran (Islamic Republic of) Iran (Islamic Republic of) aged 2-18 in both genders discontinuation of topical treatment at least 2 weeks ago and for patients who use systemic therapy, it should be stable for months (at least 2 months) and plaque lesions remain in the use of systemic therapy mild to moderate eczema 2 years 18 years Both History of allergy to the compounds in the formulation and vitamin D3 derivatives aged over 18 years Hypervitaminosis D hypercalcemia Patients with acute eczema attack The presence of skin infection or malignancy at the treatment site The presence of diseases associated with vitamin D metabolism disorders L20.9 Atopic dermatitis, unspecified Placebo Treatment - Drugs Patients in the control group should use a drug-free ointment once a day for 8 weeks on lesions.The placebo ointment contains 95% vaseline and 5% bee wax. Patients in the intervention group should use cholecalciferol 1000 unit per gram ointment once a day for 8 weeks on lesions. Quality of Life. Timepoint: beginning of the treatment, 4 weeks and 8 weeks after starting the treatment. Method of measurement: questionnaire. Eczema severity. Timepoint: beginning of the treatment, 4 weeks and 8 weeks after starting treatment. Method of measurement: EASI. Adverse effect. Timepoint: beginning of the treatment, 4 weeks and 8 weeks after starting treatment. Method of measurement: physician assessment. Pharmaceutical Sciences branch, Islamic Azad University Approved 2017-01-05 Ethics committee of Islamic Azad University Of Pharmaceutical Sciences Branch Islamic Azad University Of Pharmaceutical Sciences Branch,Yakhchal avenue,Shariati Tehran Tehran Iran (Islamic Republic of)