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IRCT201506073106N26 IRCT 2015-07-06 Islamic Azad University, Pharmaceutical Sciences Branch Effect of saqez cream on knee osteoarthritis OA osteoarthritis Comparison of the effect of pistacia atlantica oleoresin (saqez) and diclofenac gel on clinical symptoms in patients with knee osteoarthritis : A double-blind , controlled trial. 2015-04-04 anticipated 85 Complete https://irct.ir/trial/3131 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: random number table. N/A Osteoarthritis. Intervention 1: Saqez cream prepared by researcher, Knee local use, Dosage 2 grams per use, 3 times a day for 3 months. Intervention 2: Pluse control group: diclofenac gel 1 % ( Iran najo ) ,3 times daily, 2 grams, for 3 months.
public Dr. Mehdi Rajabi
No.99, Yakhchal street, Dr. Shariati Avenue
Tehran Iran (Islamic Republic of) +98 21 2264 0056 mehdirj@aol.co.uk Islamic Azad University, Pharmaceutical Sciences Branch scientific Dr. Mehdi Rajabi
No.99, Yakhchal street, Dr. Shariati Avenue
Tehran Iran (Islamic Republic of) +98 21 2264 0056 mehdirj@aol.co.uk Islamic Azad University, Pharmaceutical Sciences Branch Iran (Islamic Republic of) Inclusion criteria: Patient's written consent; radiographic changes; primary knee osteoarthritis grade 2 and 3; age between 35 – 85; patients who did not receive topical treatment or received previous topical treatment for at least two weeks before they start on this trial. All patients must be stable on their current oral therapy. Exclusion criteria: Patients who needs more than 2 grams of acetaminophen in order to control pain; Those who need to use other oral or intravenous analgesics; Unwilling to continue or to participate in the study any further; Sensitivity to study drugs; Patients with other bone joint disorders: ( Rhumatoid Arthrities, Gout, Pseudo Gout, Infected Arthrities, Metabolic Arthrities, Traumatic Arthrities ) ; Infections and malignancy disease; Joint replacement; Fibro myalgia; Knee corticosteroid injection in the past 3 months, Pregnancy, oral and local use of corticosteroids; Pationts with active Renal, Liver and Peptic Ulcer Disease; Alcohol addicted; Drug Abuse 35 years 85 years Both M19.0 Primary arthrosis of other joints Treatment - Drugs Treatment - Drugs Saqez cream prepared by researcher, Knee local use, Dosage 2 grams per use, 3 times a day for 3 months Pluse control group: diclofenac gel 1 % ( Iran najo ) ,3 times daily, 2 grams, for 3 months Physical function. Timepoint: 2 Weeks,6 weeks and 12 weeks after baseline. Method of measurement: Womac questionaries. Stiffness. Timepoint: 2 Weeks,6 weeks and 12 weeks after baseline. Method of measurement: Womac questionaries. Pain. Timepoint: 2 Weeks,6 weeks and 12 weeks after baseline. Method of measurement: Womac questionaries. Islamic Azad University, Pharmaceutical Sciences Branch Approved 2012-06-20 Ethics committee of pharmaceutical science branch of Islamic Azad University No.99, Yakhchal street, Dr. Shariati Avenue Tehran Tahran Iran (Islamic Republic of)