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IRCT20110809007265N12 IRCT 2018-06-30 Mashhad University of Medical Sciences Effect of hypericum perforatum in obesity Comparison of the effectiveness of hypericum perforatum with placebo in appetite control in obese and overweight individuals 2018-05-26 anticipated 60 Complete https://irct.ir/trial/31286 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomisation using number cards in sealed envelopes, Blinding description: Participants, major researcher, nutritionist, questioner, data analyst. 3 Obesity. Intervention 1: Intervention group: diet + exercise + Hypericum perforatum 750 mg QID for 6 weeks (made by School of Iranian and Complementary Medicine, Mashhad). Intervention 2: Control group: diet + exercise + placebo. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.
public Hoda Azizi
School of Iranian and Complementary Medicine, Azadi Square
Mashhad Iran (Islamic Republic of) 9177948564 +98 51 1855 2188 azizih@mums.ac.ir Mashhad University of Medical Sciences scientific Dr. Hoda Azizi
School of Iranian and Complementary Medicine, Azadi Square
Mashhad Iran (Islamic Republic of) 9177948564 +98 51 3855 2188 azizih@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) BMI 24.9 to 39.9 Women 18 years to premenopausal and men 18 to 60 years old Consent to participate in the study History of at least one monotherapy failure 18 years 60 years Both Hypothyroidism, Cushing's syndrome, cancer, liver or kidney failure Psychiatric disorders associated with eating like anorexia nervosa and hyperorexia Using drugs effective on weight and metabolism in the previous month Using drugs that interfere with Hypericum perforatum such as protease inhibitors, amiodarone, anticoagulants, cyclophosphamide, cyclosporine, monoamine oxidase inhibitors, phenytoin, tacrolimus, tamoxifen and trazodone drug Drug abuser or alcoholism Breast-feeding, pregnancy or planning a pregnancy during the next two months Pacemaker and any metal device inside the body due to the use of Bioelectrical Impedance Analyzer Disability to do recommended physical activity Allergy to hypericum perforatum E66.0 Obesity due to excess calories Treatment - Drugs Placebo Intervention group: diet + exercise + Hypericum perforatum 750 mg QID for 6 weeks (made by School of Iranian and Complementary Medicine, Mashhad) Control group: diet + exercise + placebo Appetite. Timepoint: Before intervention, week 3, week 6. Method of measurement: Visual Analogue Scale. Body weight. Timepoint: Before intervention, week 3, week 6. Method of measurement: Kilogram. Waist to hip ratio. Timepoint: Before intervention, week 3, week 6. Method of measurement: Centimeter. Insulin. Timepoint: Before intervention, after intervention. Method of measurement: IU. Fasting Blood Sugar. Timepoint: Before intervention, after intervention. Method of measurement: Mg/dl. Mashhad University of Medical Sciences Approved 2018-05-19 Ethics committee of Mashhad University of Medical Sciences Qorashi building, Daneshgah Street Mashhad Razavi Khorasan Iran (Islamic Republic of)