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IRCT20110809007265N11 IRCT 2018-05-23 Mashhad University of Medical Sciences Effect of Nettle in treatment of menopausal hot flash Comparison of the effect of Urtica dioica with placebo in hot flashes during menopause. 2018-05-18 anticipated 42 Complete https://irct.ir/trial/31152 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Sealed envelopes, Blinding description: Participants, researcher, questioner, and data analyzer will be blind in this study. 3 Menopause. Intervention 1: Intervention group: nettle in the form of Urtidin tablet 150 mg, 3 times/ day for 7 weeks. Intervention 2: Control group: nettle placebo tablet, three times a day for seven weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information.
public Dr Hoda Azizi
Department of Chinese and complementary medicine, School of traditional and complementary medicine, University Campus, Azadi Square
Mashhad Iran (Islamic Republic of) 9177948564 +98 51 3882 9279 azizih@mums.ac.ir Mashhad University of Medical Sciences scientific Dr Hoda Azizi
Department of Chinese and complementary medicine, School of traditional and complementary medicine, University Campus, Azadi Square
Mashhad Iran (Islamic Republic of) 9177948564 +98 51 3882 9279 azizih@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Post-menopausal women (defined as: amenorrhea for 12 months or more) who suffer from hot flashes. Age 45-60 years old Approval for treatment of hot flashes and consent to participate in the plan. 45 years 60 years Female History of hysterectomy or oophorectomy Anticancer therapies due to malignancy History of estrogen-dependent cancers over the past five years History of allergy to urticaria History of known psychiatric disorders Hyperthyroidism or hypothyroidism Conditions and physical illnesses that are not suitable for this study: Cardiovascular disease (coronary artery disease, cerebrovascular disease and thromboembolic disorders) uncontrolled Hypertension or diabetes, kidney or liver failure use of anticoagulants Taking any medication for hot flashes such as HRT and SSRI in the past eight weeks Endometrial thickness over 12 mm in uterine ultrasonography Vaginal bleeding with unknown origin in the past 6 months N95.1 Menopausal and female climacteric states Treatment - Other Placebo Intervention group: nettle in the form of Urtidin tablet 150 mg, 3 times/ day for 7 weeks. Control group: nettle placebo tablet, three times a day for seven weeks Level of FSH, estradiol, LH. Timepoint: Before the study and at week 8. Method of measurement: blood test. Severity of menopausal symptoms. Timepoint: Before the intervention, week 4 and 7. Method of measurement: Menopausal Rating Scale questionnaire. Number and severity of hot flashes per day. Timepoint: One week before the study and at weeks 5 and 8. Method of measurement: Patient Daily Report. Mashhad University of Medical Sciences Approved 2018-05-07 Ethics committee of Mashhad University of Medical Sciences Mashhad University of Medical Sciences, Daneshgah Street Mashhad Razavi Khorasan Iran (Islamic Republic of)