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IRCT20090912002445N7 IRCT 2018-05-21 Shiraz University of Medical Sciences Morphine and methadone for postoperative pain control Effects of Intraoperative Morphine and Methadone on Postoperative Pain Control in Opioid Addicted Patients undergoing Orthopedic Surgery 2016-10-01 anticipated 60 Complete https://irct.ir/trial/31134 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: All the patients will be randomized to two study groups using a computerized random digit generator based in the patients' admission number, Blinding description: This will be a double-blinded randomized clinical trial. The medications will be prepared in the same form in dark syringes and will be given to the anesthesiologist who is not aware of the content. The nurse who will record the patient postoperative pain is also unaware of the study group. The patients are also blinded toward to study intervention. 3 After surgery pain. Intervention 1: Intervention group: Intramuscular methadone (0.15 mg/kg) one hour before termination of surgery. Intervention 2: Control group: Intramuscular morphine sulphate (0.15 mg/kg) one hour before termination of surgery. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Reza Raeesi Estabragh
Anesthesiology and Intensive Care Research Center, Nemazi Hospital, Namazi Square
Shiraz Iran (Islamic Republic of) 7194815644 +98 71 3647 4270 r.raeesi@yahoo.com Shiraz University of Medical Sciences scientific Reza Raeesi Estabragh
Anesthesiology and Intensive Care Research Center, Nemazi Hospital, Namazi Square
Shiraz Iran (Islamic Republic of) 7194815644 +98 71 3647 4270 r.raeesi@yahoo.com Shiraz University of Medical Sciences Iran (Islamic Republic of) ASA Class I and II Opium Addict Elective orthopedic surgery 18 years 78 years Both ASA Class III and IV Preoperative antidepressant and anticoagulant medication Hypersensitivity to morphine Hypersensitivity to methadone R52 Pain, not elsewhere classified Treatment - Drugs Treatment - Drugs Intervention group: Intramuscular methadone (0.15 mg/kg) one hour before termination of surgery Control group: Intramuscular morphine sulphate (0.15 mg/kg) one hour before termination of surgery Postoperative pain. Timepoint: 0, 1, 3, 6, 12, 24 hours after operation. Method of measurement: Visual analogue scale. Postoperative nausea and vomitting. Timepoint: 0, 1, 3, 6, 12, 24 hours after operation. Method of measurement: Visual analogue scale. Need for rescue analgesia. Timepoint: 24 hours after the surgery. Method of measurement: Administered dosage in milligrams. Shiraz University of Medical Sciences Approved 2016-03-03 Medical Ethics Committee of Shiraz University of Medical Sciences Zand Avenue Shiraz Fars Iran (Islamic Republic of)