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IRCT138810293104N1 IRCT 2012-08-24 Deputy research and tecnology in kerman medical university Comparison the effects of fentanyl, sufentanil and alfentanil as premedication on postoperative nausea and vomiting in diagnostic gynecologic laparascopy Comparison the effects of fentanyl, sufentanil and alfentanil as premedication on postoperative nausea and vomiting in diagnostic gynecologic laparascopy in hundred eighty patients (ASA I and II), aged 18-35 year 2010-03-20 anticipated 180 Complete https://irct.ir/trial/3109 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A gynecologic. Intervention 1: Midazolam 1mg and alfentanil 2cc (1000μg). Induction of every three group was performed using thiopental (5mg/kg) and succynyl choline (1.5mg/kg), anesthesia was maintained using isoflurane 1.2% gas and a mixture of N2O-O2 with 50/50 ratio. Due to the short duration of surgery, there was no need to repeat administration of opioid drug and in the case of surgery lasting more than 45 minutes and repetition of opioid administration, patient was excluded from the study. Intervention 2: Midazolam 1mg and fentanil 2cc (100μg); was administered to the patients two minutes before I.V. induction of anesthesia to the patient (each 1cc of the three drugs has equal power). Induction of every three group was performed using thiopental (5mg/kg) and succynyl choline (1.5mg/kg), anesthesia was maintained using isoflurane 1.2% gas and a mixture of N2O-O2 with 50/50 ratio. Due to the short duration of surgery, there was no need to repeat administration of opioid drug and in the case of surgery lasting more than 45 minutes and repetition of opioid administration, patient was excluded from the study. Intervention 3: Midazolam 1mg and sufentanil 2cc (10μg) was administered to the patients two minutes before I.V. induction of anesthesia to the patient (each 1cc of the three drugs has equal power). Induction of every three group was performed using thiopental (5mg/kg) and succynyl choline (1.5mg/kg), anesthesia was maintained using isoflurane 1.2% gas and a mixture of N2O-O2 with 50/50 ratio. Due to the short duration of surgery, there was no need to repeat administration of opioid drug and in the case of surgery lasting more than 45 minutes and repetition of opioid administration, patient was excluded from the study.
public Mohammad Shabani
Kerman
Kerman Iran (Islamic Republic of) +98 34 1226 4198 shabanimoh@yahoo.com Kerman Neuroscience Research Center scientific Mohammad Shabani
Neuroscience Research Center- kerman medical universi
Kerman Iran (Islamic Republic of) +98 34 1226 4196 shabani@kmu.ac.ir Neuroscience Research Center- kerman medical university Iran (Islamic Republic of) Inclusion Criteria: Patients were selected from those who referred to afzalipoor hospital of Kerman for diagnostic GLS and were aged 18-35 with ASA I or II. Exclusion criteria: diabetes mellitus; addiction to drugs; history of nausea or vomiting and or using drugs with known anti-emetic properties (like metformin, clomifen, medroxy progestron, bromocriptin) 24 hours before the surgery; smoking; motion disease history; previous experience of PONV; surgical duration more than 45 minutes; usage of opioids after surgery in recovery period and weight more than 70kg. After signing informed consent by all the patients, 180 subjects were enrolled in the study. 18 years 35 years Female N80-N98 N80-N98 Treatment - Drugs Treatment - Drugs Treatment - Drugs Midazolam 1mg and alfentanil 2cc (1000μg). Induction of every three group was performed using thiopental (5mg/kg) and succynyl choline (1.5mg/kg), anesthesia was maintained using isoflurane 1.2% gas and a mixture of N2O-O2 with 50/50 ratio. Due to the short duration of surgery, there was no need to repeat administration of opioid drug and in the case of surgery lasting more than 45 minutes and repetition of opioid administration, patient was excluded from the study. Midazolam 1mg and fentanil 2cc (100μg); was administered to the patients two minutes before I.V. induction of anesthesia to the patient (each 1cc of the three drugs has equal power). Induction of every three group was performed using thiopental (5mg/kg) and succynyl choline (1.5mg/kg), anesthesia was maintained using isoflurane 1.2% gas and a mixture of N2O-O2 with 50/50 ratio. Due to the short duration of surgery, there was no need to repeat administration of opioid drug and in the case of surgery lasting more than 45 minutes and repetition of opioid administration, patient was excluded from the study. Midazolam 1mg and sufentanil 2cc (10μg) was administered to the patients two minutes before I.V. induction of anesthesia to the patient (each 1cc of the three drugs has equal power). Induction of every three group was performed using thiopental (5mg/kg) and succynyl choline (1.5mg/kg), anesthesia was maintained using isoflurane 1.2% gas and a mixture of N2O-O2 with 50/50 ratio. Due to the short duration of surgery, there was no need to repeat administration of opioid drug and in the case of surgery lasting more than 45 minutes and repetition of opioid administration, patient was excluded from the study. Vomitting. Timepoint: 0-24, 0-2, 2-24(0-24 hours after surgury). Method of measurement: Observation. Nausea. Timepoint: 0-24, 0-2, 2-24(0-24 hours after surgury). Method of measurement: Observation. Deputy research and tecnology in kerman medical university Approved 2009-04-21 Kerman University of Medical Sciences Ethics Committee Somayeh crossroad- Kerman Neuroscience Research Center Kerman Iran (Islamic Republic of)