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IRCT20180503039510N1 IRCT 2018-05-29 Islamic Azad University Evaluation of effect of PRP on TMD Evaluation of effect of PRP on temporomandibular disorder( TMD) 2017-01-01 anticipated 20 Complete https://irct.ir/trial/30943 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Choosing one tmj as witness and the other one as case. 3 Temporomandibular disorder(TMD). Intervention 1: Intervention group: PRP injection in temporomandibular joint of one side in included patients(20 patients are being studie)6CC of patients blood will be transfused into sterile tubes coated with anti coagulant made by CHOUKRON company and centrifuged for3 minutes with1600 r/min,after formation of 3 layers in the tube ,the middle layer including platelet rich plasma or PRP is extracted,then a line is drwn joining the tragus to the lateral canthus(in the side to be injected),0.6 ml is injected in the point 10mm anterior to tragus (in the drawn line) and 2mm below,soft diet until one week is suggested to patient . index including pain,mouth opening,joint souds and jaw deviation in opening will be registered just at the time of injection and 2,4 and 6 months later and documented in related forms. Intervention 2: Control group: The temporomandibular joint in the side which has not been injected PRP,whitout any additional procedure, is considered as control group,and the indexes pain, limitation in joint movement,joint sound and deviation of mandible in opening at the begining of study and 2,4 and six months later the as intervention side is registered and finally compared with intervention group. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is The plan for publishing is not established yet
public Mehdi Sezavar
No 5, 9thNeyestan , Pasdaran Ave
Tehran Iran (Islamic Republic of) 1913633151 +98 21 2256 4571 M_sezavar@dentaliau.ac.ir Islamic Azad University scientific Mehdi Sezavar
No 5, 9th Neyestan Alley, Pasdaran Ave
Tehran Iran (Islamic Republic of) 1913633151 +98 21 3331 1107 M_sezavar@dentaliau.ac.ir Islamic Azad University Iran (Islamic Republic of) Pain Limitation in movement Joint sounds Deviation of mandible in mouth opening no limit no limit Both Systemic deases Patient candidate for tmj surgery Disk displacement without reduction M26.6 Temporomandibular joint disorders Treatment - Other Treatment - Other Intervention group: PRP injection in temporomandibular joint of one side in included patients(20 patients are being studie)6CC of patients blood will be transfused into sterile tubes coated with anti coagulant made by CHOUKRON company and centrifuged for3 minutes with1600 r/min,after formation of 3 layers in the tube ,the middle layer including platelet rich plasma or PRP is extracted,then a line is drwn joining the tragus to the lateral canthus(in the side to be injected),0.6 ml is injected in the point 10mm anterior to tragus (in the drawn line) and 2mm below,soft diet until one week is suggested to patient . index including pain,mouth opening,joint souds and jaw deviation in opening will be registered just at the time of injection and 2,4 and 6 months later and documented in related forms. Control group: The temporomandibular joint in the side which has not been injected PRP,whitout any additional procedure, is considered as control group,and the indexes pain, limitation in joint movement,joint sound and deviation of mandible in opening at the begining of study and 2,4 and six months later the as intervention side is registered and finally compared with intervention group. Temporomandibular jointPain. Timepoint: At the begining of study and 2,4 and 6 month later. Method of measurement: Visual Analogue Scale questionarie. Islamic Azad University Approved 2016-05-15 Ethics commitee of Azad Dental School No.5 ,9 th Neyestan Alley, Pasdaran Ave Tehran Tehran Iran (Islamic Republic of)