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IRCT20180131038578N1 IRCT 2019-03-20 Shahid Beheshti University of Medical Sciences The effect of preoperative and postoperative vitamin D medication therapy on postoperative urinary IL18,KIM1levels in modarres hospital CABG patients in 1397 year The association between vitamin D medication therapy and reducing post coronary bypass graft surgery acute kidney injury in patients with low vitamin D levels. 2019-01-21 anticipated 66 Complete https://irct.ir/trial/30776 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Health service research, Randomization description: Method of randomization is simple .unit of randomization is individual. The tool of randomization is computer software, Blinding description: This study is double blinded and the participants in study,care providers, investigators and data analysers are blinded. 1 Post coronary artery bypass graft surgery acute kidney injury. Intervention 1: Intervention group: is going to be prescribed 50000 units vitamin D for 3 consecutive days , 3 times a day. vitamin D level ,IL18,KIM1is going to be measured before the surgery.IL18,KIM1is going to be measured during the surgery, the day after surgery in both groups. Intervention 2: Control group: is going to be prescribed placebo for 3 consecutive days , 3 times a day,vitamin D level ,IL18,KIM1is going to be measured before the surgery.IL18,KIM1is going to be measured during the surgery, the day after surgery. Yes - There is a plan to make this available What will be shared: Result of study on vitamin D's affects on IL18,KIM1 urine level and their association with CS-AKI. All documents will be available. When: About 6 months after publication ,data will become available. To whom: Documents will be available for academic institutions and people working in businesses. Conditions: This document coud be useful for researchers interestend in related fields . Where to obtain: Shahid beheshti university of medical sciences research affairs SBMU, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, Iran. code:1985717443 Tel : 021-23871 Email: msp@sbmu.ac.ir Dr mahnoosh foroughi researcher. Email:mahnoosh.foroughi@gmail.com Pegah eslami researcher. Email:pegahslm@gmail.com How to obtain: We will decide to accept or reject the application after a session in research center. Comments:
public Mahnoosh Foroughi
District 2,Saadat Abad Blvd
Tehran Iran (Islamic Republic of) 1998734383 +98 21 2207 4087 Mahnoosh.foroughi@gmail.com Shahid Beheshti University of Medical Sciences scientific Mahnoosh Foroughi
District 2,Saadat Abad Blvd
Tehran Iran (Islamic Republic of) 1998734383 +98 21 2207 4087 Mahnoosh.foroughi@gmail.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) CABG surgery for the first time. The patient who had just CABG surgery without another surgery at the same time, like valvular replacement. CPB usage in the surgery. Patients with vitamin D level less than 20 ng/ml. 18 years 80 years Both Taking vitamin D supplements before the study. ESRD or cr level more than 1.5 mg/dl Taking nephrotoxic drugs. Less than 3 days gap between angiography and surgery. N99.0 Postprocedural (acute) (chronic) kidney failure Prevention Prevention Intervention group: is going to be prescribed 50000 units vitamin D for 3 consecutive days , 3 times a day. vitamin D level ,IL18,KIM1is going to be measured before the surgery.IL18,KIM1is going to be measured during the surgery, the day after surgery in both groups Control group: is going to be prescribed placebo for 3 consecutive days , 3 times a day,vitamin D level ,IL18,KIM1is going to be measured before the surgery.IL18,KIM1is going to be measured during the surgery, the day after surgery The renal injury marker urinary level interlukin-18. Timepoint: Before the surgery, in no time after surgery , a day after surgery. Method of measurement: The enzyme-linked immunosorbent assay (ELISA). The renal injury marker urinary level,kidney injury molecule-1. Timepoint: Before the surgery, in no time after surgery , a day after surgery. Method of measurement: The enzyme-linked immunosorbent assay (ELISA). Bleeding . Timepoint: In no time , 6 hours , 12 hours after surgery 2. Method of measurement: Collected by chest tube by ML/Hour. Ventilation . Timepoint: During 12 hours after CABG surgery. Method of measurement: Ventilator for ventilation measuring by per hour. Packed RBC cell transfusion . Timepoint: During 12 hours after CABG surgery . Method of measurement: packed RBC cell bag for transfusion. Creatinine serum levels . Timepoint: In no time before the surgery, after surgery and the day after surgery. Method of measurement: Laboratory test for creatinine. Shahid Beheshti University of Medical Sciences Approved 2019-01-15 Ethics committe of shahid beheshti university of medical sciences Velenjak St. , Shahid Chamran Highway Tehran Tehran Iran (Islamic Republic of)