IRCT201604253043N11 IRCT 2016-05-21 Tehran University of Medical Sciences Comparing the starting time of tacrolimus administration in management of kidney transplant recipients Comparing de novo versus delayed tacrolimus administration on allograft function in kidney transplant recipients: a randomized, open-label, clinical trial 2016-05-21 anticipated 50 Complete https://irct.ir/trial/3056 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. 3 Kidney transplant. Intervention 1: Intervention 1: Tacrolimus will be started from a few hours before transplantation at a dose of 0.08 to 0.1 mg / kg / day in two divided doses ( The target level of 8-10 ng / ml). Serum creatinine and urine output will be assessed daily during hospitalization. Serum creatinine witll be assessed monthly after hospital discharge up to month 3 after kidney transplantatioد. Tacrolimus whole blood concentrations will be checked twice weekly during hospitalizations and monthly thereafter up to month 3 after transplantation. Intervention 2: Intervention 2:Tacrolimus will be started from the third day after kidney transplantation at a dose of 0.08 to 0.1 mg / kg / day in two divided doses (The target level of 8-10 ng / ml). Serum creatinine and urine output will be assessed daily during hospitalization. Serum creatinine witll be assessed monthly after hospital discharge up to month 3 after kidney transplantation. Tacrolimus whole blood concentrations will be checked twice weekly during hospitalizations and monthly thereafter up to month 3 after transplantation.