IRCT20130726014170N2 IRCT 2018-04-23 Arak University of Medical Sciences The Effectiveness of Ondonestrone and Granisetron in the Treatment of Obsessive-Compulsive Disorder Comparison of Ondansetron and Granisetron Effectiveness in the Treatment of Obsessive-Compulsive Disorder with Inadequate Response to Selective Serotonin Reuptake Inhibitors 2014-08-20 anticipated 104 Complete https://irct.ir/trial/30516 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization of patients is based on the use of the random permuted block method (allocation ratio 1:1, blocks of four). Treatment allocation is concealed from the participants and physicians rated the patients using sequentially numbered, opaque and sealed envelopes. Randomizations and ratings of the patients are performed by separate individuals, Blinding description: The patients, the psychologist who referred the patients, the general physician and psychologist who evaluated the patients and prescribed the medication and the statistician were all blind to allocation. 3 obsessive-compulsive disorder. Intervention 1: Intervention group: Continued treatment with serotonin reuptake inhibitor along with oral ondansetron tablet 2 mg in twice daily (4 mg daily) for 18 weeks. Ondansetron was provided by Jaber Ibn Hayyan pharmaceutical company,Tehran, Iran. Intervention 2: Intervention group: Continued treatment with serotonin reuptake inhibitor along with oral granisetron tablet 1 mg in twice daily (2 mg daily) for 18 weeks. Granisetron was provided by Jaber Ibn Hayyan pharmaceutical company,Tehran, Iran. Intervention 3: Control group: Oral placebo tablets were administered daily for 18 weeks. The placebo were provided by Jaber Ibn Hayyan pharmaceutical company, Iran. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information