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IRCT20150531022498N23 IRCT 2018-07-06 Rasht Azad University A comparison of the effects of 12 weeks walking with two different intensities on the expression of circulating miR-146a, miR-181a and Plasma levels of inflammatory markers IL-6 and TNF-α In Sedentary Aged Women. A comparison of the effects of 12 weeks walking with two different intensities on the expression of circulating miR-146a and miR-181a and Plasma levels of inflammatory markers IL-6 and TNF-α In Sedentary Aged Women. 2018-04-21 anticipated 50 Complete https://irct.ir/trial/30511 observational Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Subjects were divided into 3 groups (one control group and 2 experimental groups) using the random numbers table. N/A Diseases associated with aging and inflammation. Intervention 1: The first Intervention group: moderate intensity of walking, In this group, the subjects will be walking(55-50% of the target heart rate) for 12 weeks and 3 sessions in a week. The workout time of the first week will begin at 30 minutes and will increase to 45 minutes at the end of the sixth week. The intensity of exercise in the first six weeks will be 50% of the maximum heart rate reserved and in the second six weeks it will be 55%. Intervention 2: The second Intervention group: High intensity of walking,In this group, the subjects will be walking(70-75% of the target heart rate) for 12 weeks and 3 sessions in a week. The workout time of the first week will begin at 30 minutes and will increase to 45 minutes at the end of the sixth week. The intensity of exercise in the first six weeks will be 70% of the maximum heart rate reserved and in the second six weeks it will be 75%. Intervention 3: Control group: Without any intervention, subjects in this group will continue their normal routine during the 12-week study period. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no more information
public Fateme Falah
Imam Khomeini Squ,.Baghestan St,. Alborz province
Alborz Iran (Islamic Republic of) 3193747846 +98 26 3452 4701 fatemefalah1363@gmail.com Rasam university of Alborz province scientific Fateme Falah
Ibn Sina St, District 4, Rasht., Guilan Province.
Rasht Iran (Islamic Republic of) 4147654919 +98 13 3342 2153 fatemefalah1363@gmail.com The University of Guilan Iran (Islamic Republic of) Women Age range 60 to 75 Inactive 60 years 75 years Female Having any chronic and inflammatory disease Having any particular diet or medication during the study period Use of auxiliary equipment for walking Motor limitation in the pelvic, hip and knee joints Rehabilitation Rehabilitation Rehabilitation The first Intervention group: moderate intensity of walking, In this group, the subjects will be walking(55-50% of the target heart rate) for 12 weeks and 3 sessions in a week. The workout time of the first week will begin at 30 minutes and will increase to 45 minutes at the end of the sixth week. The intensity of exercise in the first six weeks will be 50% of the maximum heart rate reserved and in the second six weeks it will be 55%. The second Intervention group: High intensity of walking,In this group, the subjects will be walking(70-75% of the target heart rate) for 12 weeks and 3 sessions in a week. The workout time of the first week will begin at 30 minutes and will increase to 45 minutes at the end of the sixth week. The intensity of exercise in the first six weeks will be 70% of the maximum heart rate reserved and in the second six weeks it will be 75%. Control group: Without any intervention, subjects in this group will continue their normal routine during the 12-week study period. Plasma level of miR-146a. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by polymerase chain reaction (PCR). Plasma level of microRNA-181a. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by polymerase chain reaction (PCR). Plasma level of Interleukin-6. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Serum level using ELISA Kit. Plasma level of Tumor necrosis factor alpha (TNF-α). Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Serum level using ELISA Kit. White blood cell counts. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using blood sample. Blood pressure variables. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Rest levels using by measurement of systolic blood pressure, diastolic blood pressure and heart rate. Quality of life. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by quality of life questionnaire (SF-36). Body composition. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by measurement of weight, body mass index (BMI), fat percent, fat free mass and waist circumference. Physical fitness. Timepoint: Before and after the end of 12 weeks of training. Method of measurement: Using by measurement of dynamic and static balance and maximum oxygen consumption (VO2max). Rasht Azad University Approved 2017-09-19 Ethics committee of Rasht Azad University lbn Sina St, District 4, Rasht., Gilan Province. Rasht Guilan Iran (Islamic Republic of)