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IRCT20171128037667N1 IRCT 2018-04-28 Islamic Azad University The Effect of Eight-Week Concurrent Training on Expression of Tumor Suppressor Genes in Men with Prostate Cancer The Effect of Eight-Week Concurrent Training on Expression of P53 and P21 Tumor Suppressor Genes in Men with Prostate Cancer 2018-03-06 anticipated 25 Complete https://irct.ir/trial/30108 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Other, Purpose: Supportive, Randomization description: due to the health status and acceptance of the patients to the testing stages, use the selection method the maximum sample in the Morgan table, 20 men aged 51-75 years old and BMI of 23-29 kg / m2 randomly divided in to two groups of 10 Control unit and experimental. N/A prostate cancer. Intervention 1: Intervention group: Experimental group with practice protocol contain a concurrent training course (aerobic-resistance) that designed by the researcher (according to the American College of Medicine-Sports) for three days a week for 8 weeks. The Concurrent training program combines endurance training and resistance training that runs in two equal time steps which includes 55 minutes of training in the first and second weeks to 70 minutes in the seventh and eighth weeks. Warm up for 10 minutes Then Resistance training program included four movements of upper and lower large muscle groups that will be excuted three session per week with a severity of 60 to 75%, one repetition maximum, and for two time with 10 repetitions and three-minute break between turns. The beginning of the course with 60% of maximal repetition that increases by five percent every two weeks. Aerobic exercise with 15 minutes of activity with 60% heart rate maximum, starting at three sessions per week, which is performed with resistance training in one session. [based on the maximum heart rate equation: [(220-years)±10]. Starting The course with 60% maximum heart rate will be added every two weeks 5% to this amount and Five minutes to period. At the end of each exercise session, 10 minutes recovery to original state and cool down (slow running, walking and tensile movements for recovery) will be done. Intervention 2: Control group: The control group will continue to perform its daily activities and was requested to no participate in exercise training during this period. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information
public mohammad asghari rekabdarkolaee
Islamic Azad University Ayatollah Amoli Branch, University feeder, old road Amol to Babol 5 km, Amol
Amol Iran (Islamic Republic of) 4771653646 +98 11 4253 2765 asghari.moh@gmail.com Islamic Azad University scientific Alireza barari
Islamic Azad University Ayatollah Amoli Branch, University feeder, old road Amol to Babol 5 km, Amol
Amol Iran (Islamic Republic of) 4635143358 +98 11 4321 7126 alireza54.barari@gmail.com Islamic Azad University Iran (Islamic Republic of) Subjects are putted at the stage T1 and T2 of the disease and are treated under the same way. The entering criteria for the study include: Physical health based on a medical history questionnaire that has no history of cardiovascular disease, high blood pressure, diabetes, renal disease, no smoking or participation in any exercise program at least 2 months before take part in Exercise Training program Subjects get allowed to enter the project after a cardiovascular examination, blood pressure measurement and ECG monitoring by a specialist. Take The Physical activities readiness questionnaire (PAR-Q) and The informed consent form for participation in this research by subjects. no limit no limit Male Not attending more than 3 sessions having of heart or lung disease Change in health that prevent physical activity D07.5 Carcinoma in situ of prostate Rehabilitation N/A Intervention group: Experimental group with practice protocol contain a concurrent training course (aerobic-resistance) that designed by the researcher (according to the American College of Medicine-Sports) for three days a week for 8 weeks. The Concurrent training program combines endurance training and resistance training that runs in two equal time steps which includes 55 minutes of training in the first and second weeks to 70 minutes in the seventh and eighth weeks. Warm up for 10 minutes Then Resistance training program included four movements of upper and lower large muscle groups that will be excuted three session per week with a severity of 60 to 75%, one repetition maximum, and for two time with 10 repetitions and three-minute break between turns. The beginning of the course with 60% of maximal repetition that increases by five percent every two weeks. Aerobic exercise with 15 minutes of activity with 60% heart rate maximum, starting at three sessions per week, which is performed with resistance training in one session. [based on the maximum heart rate equation: [(220-years)±10]. Starting The course with 60% maximum heart rate will be added every two weeks 5% to this amount and Five minutes to period. At the end of each exercise session, 10 minutes recovery to original state and cool down (slow running, walking and tensile movements for recovery) will be done. Control group: The control group will continue to perform its daily activities and was requested to no participate in exercise training during this period. P53 tumor suppressor protein. Timepoint: Before the intervention and the end of the intervention. Method of measurement: Blood samples will be collected 24 hours before the training starts and 48 hours after the last exercise session. P21 tumor suppressor protein. Timepoint: Before the intervention and the end of the intervention. Method of measurement: Blood samples will be collected 24 hours before the training starts and 48 hours after the last exercise session. Aerobic capacity. Timepoint: Before the intervention and the end of the intervention. Method of measurement: To estimate the maximum oxygen consumption, the Modified Bruce test on the treadmill [based on the maximum oxygen consumption equation: 8.545 + (test run time×2.282)]. Islamic Azad University Approved 2018-03-03 Ethics Committee of Shahid Beheshti University of Medical Sciences 7th Floor, Bldg No.2 SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)