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IRCT20180301038906N1 IRCT 2018-06-10 Mashhad University of Medical Sciences adding memantine to treatment of schozopherenia Adjunctive Memantine Therapy for Negative Symptoms in Schizophrenia: A Double-Blind Placebo Controlled Study 2015-04-01 anticipated 60 Complete https://irct.ir/trial/29985 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Computerized table of random numbers, Blinding description: In this double-blind study, the method of blindness is as follows, and all of the following are blind to intervention. The doctor and the people who take care of the patients A resident who collects data. 3 schizopherenia. Intervention 1: Intervention group: For patients, a daily dose of 5 mg of memantine was started, with a dose of 5 mg a week to reach 20 mg / day (in two doses)..Patients in both groups "had an atypical antipsychotic drug, including risperidone and olanzapine. Intervention 2: Control group: For patients, a daily dose of 5 mg of memantine was started, with a dose of 5 mg a week to reach 20 mg / day (in two doses).Patients in both groups "had an atypical antipsychotic drug, including risperidone and olanzapine. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Then the full consent of the authors and participants
public Raheleh Jahantigh
Hore ameli
Mashhad Iran (Islamic Republic of) 4915773335 +98 989157030782 MohammadzadehA931@mums.ac.ir Mashhad University of Medical Sciences scientific Raheleh Jahantigh
Hore ameli
Mashhad Iran (Islamic Republic of) 4915773335 +98 51 3711 2722 MohammadzadehA931@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Schizophrenia in the relative recovery period Use of atypical antipsychotics including risperidone and olanzapine No other drugs (except anticholinergic and benzodiazepine) Lack of pregnancy or breastfeeding No serious organic disease and no drug use at the time of entering the study no limit no limit Both There is serious organic disease Pregnancy or breastfeeding Existence of dementia F20 Schizophrenia Treatment - Drugs Treatment - Drugs Intervention group: For patients, a daily dose of 5 mg of memantine was started, with a dose of 5 mg a week to reach 20 mg / day (in two doses)..Patients in both groups "had an atypical antipsychotic drug, including risperidone and olanzapine. Control group: For patients, a daily dose of 5 mg of memantine was started, with a dose of 5 mg a week to reach 20 mg / day (in two doses).Patients in both groups "had an atypical antipsychotic drug, including risperidone and olanzapine. The condition of psychotic symptoms. Timepoint: Week 2,4,6. Method of measurement: wechsler. Cognitive and negative symptoms. Timepoint: week 2,4,6. Method of measurement: wechsler. Mashhad University of Medical Sciences Approved 2015-03-03 The Ethics Committee of Mashhad University of Medical Sciences Ibn Sina Hospital mashhad Razavi Khorasan Iran (Islamic Republic of)