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IRCT20131214015782N7 IRCT 2018-05-07 Tehran Dental Branch, Islamic Azad University Effect of Nabumetone on pain ‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍‍ The comparison of prophylactic prescription of Nabumetone and Ibuprofen on postoperative pain in symptomatic irreversible pulpitis 2639-04-21 anticipated 88 Pending https://irct.ir/trial/29950 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: balanced block randomization, Blinding description: double blind study: 1.researcher who prescribes drugs is blinded to the case & placebo medications due to all medications are encapsulated in identical size & shape capsules in pharmaceutical company. 2.patient is also blinded due to who does not know about the containing capsules. 3.outcome assessor is the main researcher who does not know about the prescribed medications. 4. statistician is absolutely blinded to prescription and assessment. 3 post operative endodontic pain. Intervention 1: "Intervention group1":Nabumetone 750 mg, non steroidal anti-inflammatory drugs prescribe 30 minutes before intervention. Intervention 2: "Intervention group": Nabumetone 500 mg non steroidal anti-inflammatory drugs prescribe 30 minutes before intervention. Intervention 3: "Intervention group": Ibuprofen 400 mg non steroidal anti-inflammatory drugs prescribe 30 minutes before intervention. Intervention 4: "Control group": Placebo , prescribe 30 minutes before intervention. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Peyman Mehrvarzfar
No.4, Neyestan10 Alley, Pasdaran Street
Tehran Iran (Islamic Republic of) 19585175 +98 21 2256 4571 p_mehrvarzfar@dentaliau.ac.ir Islamic Azad University scientific Peymam Mehrvarzfar
No.4, Neyestan10 Alley, Pasdaran Street
Tehran Iran (Islamic Republic of) 19585175 +98 21 2256 4571 P_mehrvarzfar@dentaliau.ac.ir Islamic Azad University Iran (Islamic Republic of) symptpmatic irreversible pulpitis healthy participants( ASAI &ASAII) first & second molar of maxilla & mandible 18 years 65 years Both systemic disease pregnancy and lactation taking analgesics in the last 12 hours allergic drugs periodontitis & PDLwidening more than 1 mm History of RCT Treatment - Drugs Treatment - Drugs Treatment - Drugs Placebo "Intervention group1":Nabumetone 750 mg, non steroidal anti-inflammatory drugs prescribe 30 minutes before intervention. "Intervention group": Nabumetone 500 mg non steroidal anti-inflammatory drugs prescribe 30 minutes before intervention. "Intervention group": Ibuprofen 400 mg non steroidal anti-inflammatory drugs prescribe 30 minutes before intervention. "Control group": Placebo , prescribe 30 minutes before intervention. Pain severity. Timepoint: measurement of pain severity before Intervention & 6,12,24,48 hours after finish the Intervention. Method of measurement: heft parker visual analog scale (0_170 mm). Tehran Dental Branch, Islamic Azad University Approved 2017-06-18 ٍٍEthics Committee of Tehran Medical Science Branch, Islamic Azad University No.4, Neyestan 10 Alley, Pasdaran Street Tehran Tehran Iran (Islamic Republic of)