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IRCT20080901001174N11 IRCT 2018-03-26 Rasht University of Medical Sciences Effect of Edible herbal oils on wound size The Effect of oral Flaxseed oil And Olive oil on wound size and Inflammation markers in burn patients 2018-03-06 anticipated 112 Complete https://irct.ir/trial/29848 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients who referred to this center with% 20-50% burns are randomly divided into four groups using randomized blocks. Intervention variables include age and sex, and patients under the transplanted skin that can be controlled and categorized in a random blocked stratified method, Blinding description: Odorless olive oil and flaxseed oil in dark glass without the name (nickname) are prepared and maintained by the Investigator. Not patients, nor nutritionists, know the type of oil. Vegetable oil is intended for use by a Nutritionist who does not know about the contents of the glass in the patient's salad, or if the patient is discharged, dark glass bottle contains unnamed oil, would be Available to the patient. It should be noted that both oils are golden yellow. Flaxseed oil has very little odor for 7 days and can not be distinguished from odorless olive oil. 3 Wound size. Intervention 1: Intervention group 1: 28 patients are in group A and receive 30 cc of olive oil mixed with salad, daily, in a meal for 21 consecutive days.Extra virgin olive oil from olives was prepared by household oiling machines. Analysis of fatty acid profiles and antioxidants and its polyphenols by GC / MS machine in Raymi chemical specialty lab using gas chromatography and spectroscopy at www.afshinrahimilab.com will be done. Intervention 2: Intervention group 2: 28 patients are in group B and receive 30 cc of Flaxseed oil mixed with salad, daily, in a meal for 21 consecutive days. Extract of flaxseed oil from flaxseed was prepared by household oiling machines. Analysis of fatty acid profiles and antioxidants and its polyphenols by GC / MS machine in Raymi chemical specialty lab using gas chromatography and spectroscopy at www.afshinrahimilab.com will be done. also, titration of peroxide endometritis on flaxseed oil will be done and will be expressed in milligrams of active oxygen in a kilogram of oil. Intervention 3: Intervention group 3: 28 patients are in group D and receive 15 ccs of Flaxseed oil mixed with 15 ccs of olive oil salad, daily, in a meal for 21 consecutive days. Intervention 4: Control group: 28 patients are in group C and they will eat the salad without oil In a meal, for 21 consecutive days. Patients'salads are based on the diet adjusted by the nutritionist to suit each patient. All four groups will receive routine treatment, which includes vitamin E and vitamin A on a daily basis. Yes - There is a plan to make this available What will be shared: Main and total Data When: starting in 2018 To whom: Universities and scientific institutions Conditions: If they cite the article Where to obtain: executor of proposal How to obtain: Contact with proposal executor and making ethical agreement Comments:
public Atefeh Ghanbari
Faculty of Nursing and Midwifery, Daneshjo street,Shahid Beheshti Highway, Rasht
Rasht Iran (Islamic Republic of) 3984141469 +98 33555056 at_ghanbari@gums.ac.ir Rasht University of Medical Sciences scientific Atefeh Ghanbari
Faculty of Nursing and Midwifery, Daneshjo street,Shahid Beheshti Highway, Rasht
Rasht Iran (Islamic Republic of) 3984141469 +98 33555056 at_ghanbari@gums.ac.ir Rasht University of Medical Sciences Iran (Islamic Republic of) Age of 15–65 years Body mass index (BMI) of 18–30 kg/m2 Hospitalization for more than 24 hours Admittion within 24 - 48 h post-burn Willingness to participate Able to feed through the mouth 15 years 65 years Both Infected burn wounds Cases of chronic and underlying diseases Allergy to Flaxseed oil And Olive oil The history of taking omega-3 and omega-6 in the previous week or month pregnant and lactating women Smoking Treatment - Other Treatment - Other Treatment - Other Treatment - Other Intervention group 1: 28 patients are in group A and receive 30 cc of olive oil mixed with salad, daily, in a meal for 21 consecutive days.Extra virgin olive oil from olives was prepared by household oiling machines. Analysis of fatty acid profiles and antioxidants and its polyphenols by GC / MS machine in Raymi chemical specialty lab using gas chromatography and spectroscopy at www.afshinrahimilab.com will be done. Intervention group 2: 28 patients are in group B and receive 30 cc of Flaxseed oil mixed with salad, daily, in a meal for 21 consecutive days. Extract of flaxseed oil from flaxseed was prepared by household oiling machines. Analysis of fatty acid profiles and antioxidants and its polyphenols by GC / MS machine in Raymi chemical specialty lab using gas chromatography and spectroscopy at www.afshinrahimilab.com will be done. also, titration of peroxide endometritis on flaxseed oil will be done and will be expressed in milligrams of active oxygen in a kilogram of oil. Intervention group 3: 28 patients are in group D and receive 15 ccs of Flaxseed oil mixed with 15 ccs of olive oil salad, daily, in a meal for 21 consecutive days. Control group: 28 patients are in group C and they will eat the salad without oil In a meal, for 21 consecutive days. Patients'salads are based on the diet adjusted by the nutritionist to suit each patient. All four groups will receive routine treatment, which includes vitamin E and vitamin A on a daily basis. Wound size. Timepoint: Before intervention and 2, 9, 15, and 22 days after the intervention. Method of measurement: Getting photo from burn injury and measure the length and width of the wound to measure the area of the wound; Canon's camera model and a standard ruler will be used for this purpose. The area of the wound is measured by the AutoCAD software. Changing the area and the appearance of the wound will be considered as wound healing. When the wound appearance become pink and transparent with the non-secreting epithelium the wound will be considered as healed wound. Hs-CRP. Timepoint: At the beginning and at the end of the study. Method of measurement: Blood test. Ferritin. Timepoint: At the beginning and at the end of the study. Method of measurement: Blood test. Albumin. Timepoint: At the beginning and at the end of the study. Method of measurement: Blood test. Rasht University of Medical Sciences Approved 2018-02-26 Ethical committee, Guilan University of Medical Sciences Guilan University of Medical Sciences, Namjoo Street Rasht Guilan Iran (Islamic Republic of)