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IRCT20141009019470N84 IRCT 2019-07-30 Shiraz University of Medical Sciences Dexamethasone Compared with Dexmedetomidine as an adjuvant to Bupivacaine for Supraclavicular Brachial Plexus Block Dexamethasone Compared with Dexmedetomidine as an adjuvant to Bupivacaine for Supraclavicular Brachial Plexus Block 2019-09-15 anticipated 70 Complete https://irct.ir/trial/29835 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are randomly divided into two groups according to the table provided by Randomization.com and using Random permutations, Blinding description: The same syringes containing 1 ml of dexamethasone or 1 ml of dexamethasone (0.5 cc dexamethasone diluted with half a cc distilled water), which are provided by a researcher, syringes are labeled only with the number, and the investigator dose not intervene in the Supraclavicular Brachial Plexus Block . 2-3 Forearm bones fracture. Intervention 1: Intervention group: Patients in the intervention group one receive 24 ml of bupivacaine(bupivacaine,Mylan,A.S.A, France)( 0.5%) plus 1 ml of dexamethasone (4 mg)(Caspian, Iran) for supraclavicular block. Intervention 2: Intervention group: In the second group, patients receive 24 ml of bupivacaine (bupivacaine,Mylan,A.S.A, France)( 0.5%) plus 0.5 ml of doxedemotomidine (Hospiar,INC,Lake Forest, USA) (50 μg) for supraclavicular block. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Its against our policy.
public Isaa Ahmadizadeh
Anesthesiology Department, Faghihi Hospital, Zand Street
Shiraz Iran (Islamic Republic of) 7134844119 +98 71 3647 4270 isaahmadizadeh@yahoo.com Shiraz University of Medical Sciences scientific Afshin Amini
Anesthesiology Department, Faghihi Hospital, Zand Street
Shiraz Iran (Islamic Republic of) 7134844119 +98 71 3647 4270 afshinaminie@yahoo.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Age 21 to 60 years old Fractures of the forearm surgeries under supraclavicular plexus block 21 years 60 years Both Heart disease Patients with high blood pressure Bradycardia Hyperthyroidism Cardiac Blocks of Grade 1,2,3 Use of adrenoreceptor agonist and antagonist Peripheral neuropathy pregnant women Patients who are addicted to narcotics and stimulant drugs Patients susceptible or allergic to the drugs studied Coagulation disorders Local infections Patient refusal M96.63 Fracture of radius or ulna following insertion of orthopedic implant, joint prosthesis, or bone plate Treatment - Drugs Treatment - Drugs Intervention group: Patients in the intervention group one receive 24 ml of bupivacaine(bupivacaine,Mylan,A.S.A, France)( 0.5%) plus 1 ml of dexamethasone (4 mg)(Caspian, Iran) for supraclavicular block. Intervention group: In the second group, patients receive 24 ml of bupivacaine (bupivacaine,Mylan,A.S.A, France)( 0.5%) plus 0.5 ml of doxedemotomidine (Hospiar,INC,Lake Forest, USA) (50 μg) for supraclavicular block. Duration of sensory block. Timepoint: 15 and 30 minutes after entering the recovery and 1,2,4,6,12,18,24 in the ward. Method of measurement: pinprick. Onset of the sensory block. Timepoint: At 0.1, 5. 10, 15, 20, 25 and 30 min after the injection of anesthetics. Method of measurement: pinprick. Duration of the motor block. Timepoint: 15 and 30 minutes after entering the recovery and 1,2,4,6,12,18,24 in the ward. Method of measurement: Bromage. Onset of the motor block. Timepoint: 15 and 30 minutes after entering the recovery and 1,2,4,6,12,18,24 in the ward. Method of measurement: Bromage. Shiraz University of Medical Sciences Approved 2017-10-25 Ethics committee of Shiraz University of Medical Sciences Vice chancellor of research,7th floor of central building of Shiraz University of Medical Sciences, Zand street Shiraz Fars Iran (Islamic Republic of)