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IRCT20170809035599N1 IRCT 2019-02-19 Ahvaz University of Medical Sciences Effect of Cordia Myxa,s herbal syrup on the Treatment of Dry Coughing Comparison of Cordia Myxa,s herbal syrup and Diphenhydramine in the treatment of dry cough 2018-11-11 anticipated 124 Complete https://irct.ir/trial/29775 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: At first, both Diphenhydramine and Cordia Myxa,s herbal syrup are packed in the same boxes. Different serial numbers are placed on the boxes where the medications can be separated. We use simple randomization model using random number table (computer randomization method). The advantages of this kind of randomization are that the type of treatment allocated to the two groups is totally unpredictable and, according to the theory of probabilities, it can be guaranteed that in a large number, the sample size of the study will be similar in the intervention and control groups. It should be noted, that the implementation of this method is very simple. Since we have a complete list of elements that constitute the population, we use individual sampling. In this research, we use a randomized numbers table as randomization method, which is a computational method for generating a sequence of numbers that do not have a specific pattern. A random number is a mode of possible state that is selected during a random event. This method starts with a random initial number (core). Then we put this number into power 2 and select its middle numbers. The number of selected numbers is equal to the number of core digits. Then, after putting the zero point at the beginning of the generated middle number, the random number is obtained and according to the specific mathematical algorithm, the sequence numbers are generated. Any number is independent from other numbers, Blinding description: the researcher and the volunteer participate in this study are completely unaware of the final stage of extracting the final information from the drugs that are presented separately by the pharmacist which are identical in appearance were placed in identical bottles. 3 dry cough. Intervention 1: Intervention group: The recipients of Cordia Myxa,s herbal syrup (62 patients)Cordia Myxa,s herbal syrup produced in pharmaceutical technology incubator of Ahvaz jundishapur University of medical sciences. Dosage: 5mg/kg/day in 4 divided doses (orally). Survey: after 72 hours from initial intervention, the number and severity of patients night and day cough will check. Intervention 2: Control group: The recipients of Diphenhydramine syrup (62 patients)Diphenhydramine syrup produced in Alborz Darou Pharmaceuticals Company.Dosage: 5mg/kg/day in 4 divided doses (orally).Survey: after 72 hours from initial intervention, the number and severity of patients night and day cough will check. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information
public Amanollah Zarei Ahmady
Golestan
ahvaz Iran (Islamic Republic of) 6185676789 +98 61 3336 1969 amanazarei@ymail.com Ahvaz University of Medical Sciences scientific Amanollah Zarei Ahmady
Golestan
ahvaz Iran (Islamic Republic of) 15794-61357 +98 61 3373 8382 amanzarei@ymail.com Ahvaz University of Medical Sciences Iran (Islamic Republic of) Children aged 6-12 years who referred to the clinic with the main complaint of acute cough and without foreign body aspiration on the first or second day of coughing. The associated symptoms include upper respiratory tract infections, mild fever (oral temperature 37.8-38.3), rhinorrhea, sneezing, mild sore throat, mild headache, Mild nasal congestion, hoarse voice, conjunctivitis. 6 years 12 years Both Symptoms of bacterial infection of the upper respiratory tract: middle to sever fever, severe sore throat with ingestion, nausea, vomiting, abdominal pain and severe headache. The presence of symptoms of lower respiratory tract infection: high fever, cough, dyspnea, boredom, chest pain and tachypnea pain. The presence of symptoms of airway reactions including wheezing, tachypnea, dyspnea. Signs of allergy such as the presence of symptoms of nose and eye itching, or a history of repetitions of similar symptoms and outer body spiration. Avoid taking medication before referral Start the symptoms of otitis or sinusitis. Start symptoms of low respiratory involvement. R05 Cough Treatment - Drugs Treatment - Drugs Intervention group: The recipients of Cordia Myxa,s herbal syrup (62 patients)Cordia Myxa,s herbal syrup produced in pharmaceutical technology incubator of Ahvaz jundishapur University of medical sciences. Dosage: 5mg/kg/day in 4 divided doses (orally). Survey: after 72 hours from initial intervention, the number and severity of patients night and day cough will check. Control group: The recipients of Diphenhydramine syrup (62 patients)Diphenhydramine syrup produced in Alborz Darou Pharmaceuticals Company.Dosage: 5mg/kg/day in 4 divided doses (orally).Survey: after 72 hours from initial intervention, the number and severity of patients night and day cough will check. Cough. Timepoint: One day before the intervention and three days after the intervention began. Method of measurement: The number and severity of patients' night and day coughing. Ahvaz University of Medical Sciences Approved 2018-01-16 Ethics committee of Ahvaz University of Medical Sciences Golestan Ahvaz Khouzestan Iran (Islamic Republic of)