IRCT20180218038785N1 IRCT 2018-03-15 Deputy of Research and Technology Development of Tabriz University Effects of pilates training and turmeric supplementation on SIRT1, Klotho gene and Quality of life Effects of 12 weeks of pilates training and turmeric supplementation on SIRT1, Klotho gene and Quality of life in middle-aged Overweight females 2018-04-02 anticipated 48 Complete https://irct.ir/trial/29701 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Factorial, Purpose: Prevention, Randomization description: Using random numbers table, individuals were grouped into four groups, Blinding description: Blinding is carried out in the distribution of turmeric and placebo capsules so that the third person (researcher assistant) will distribute the capsules and and the participants and researchers do not know if they are receiving capsules of turmeric or placebo. N/A Aging. Intervention 1: Intervention group (training) : Participate in 12 weeks of Pilates training (3 sessions per week with intensity of 40 -70 % maximum heart rate). Intervention 2: Intervention group (supplement): Daily consumption of three tablets of 700 mg turmeric, 20 min after meal. Intervention 3: Intervention group ( training-supplement): Participate in 12 weeks of Pilates training (3 sessions per week with intensity of 40 -70 % maximum heart rate) and daily consumption of three tablets of 700 mg turmeric, 20 min after meal. Intervention 4: Control group: daily consumption of three placebo tablets of 700 mg starch, 20 min after meal. No - There is not a plan to make this available Justification or reason for not sharing IPD is Abuse is possible