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IRCT20151020024625N6 IRCT 2018-02-27 Semnan University of Medical Sciences Effect of Ketamine and lidocaine on Pain following laparoscopic cholecystectomy Effect of intraperitoneal irrigation with Ketamine in comparison with lidocaine on Pain following laparoscopic cholecystectomy, a randomized clinical trial 2017-10-12 anticipated 96 Complete https://irct.ir/trial/29644 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Patients will be entered into one of the three groups by block randomization method (6-blocks), Blinding description: The patient, person who assessing pain and data analyst are not aware of the patient's group. 2-3 Post Operative pain. Intervention 1: Intervention group 1: Surgical Site Irrigation will done by 100 cc normal saline 0.9% containing 3 mg / kg Lidocaine 1% for 5-10 minutes.Then all the fluid in the surgical site is suctioned as far as possible and at the end of the surgery the peritoneal air will be suctioned and the air in the posterior area of the liver is also actively suctioned. Intervention 2: Intervention group 2: In the second group of patients, the Surgical Site Irrigation will done by 100 cc of 0.9% saline solution containing 0.5 mg / kg of ketamine for 5 to 10 minutes.Then all the fluid in the surgical site is suctioned as far as possible and at the end of the surgery the peritoneal air will be suctioned and the air in the posterior area of the liver is also actively suctioned. Intervention 3: Control group: In the third group, the Surgical Site Irrigation will done by 100 ml of normal saline for 5 to 10 minutes.Then all the fluid in the surgical site is suctioned as far as possible and at the end of the surgery the peritoneal air will be suctioned and the air in the posterior area of the liver is also actively suctioned. Yes - There is a plan to make this available What will be shared: Results of statistical Analysis When: After completing the project To whom: Only the study researchers and Referee Conditions: For similar studies Where to obtain: Dr Hamid Reza Hemmati How to obtain: Calling and Email Comments:
public Dr. Hamid Reza Hemmati
Basidj Boulevard
Semnan Iran (Islamic Republic of) 3519899951 +98 23 3142 2120 dr.hemmati2007@yahoo.com Semnan University of Medical Sciences scientific Dr. Hamid Reza Hemmati
Basidj Boulevard
Semnan Iran (Islamic Republic of) 3519899951 +98 23 3142 2120 dr.hemmati2007@yahoo.com Semnan University of Medical Sciences Iran (Islamic Republic of) Patients with Chronic Cholecystitis Candidate for elective Laparoscopic Cholecystectomy no limit no limit Both Presence of severe inflammation and adhesion at the site of surgery so that laparoscopic surgery is not possible. Rupture of the gallbladder and bile leakage at the site of surgery R52 Pain, unspecified Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group 1: Surgical Site Irrigation will done by 100 cc normal saline 0.9% containing 3 mg / kg Lidocaine 1% for 5-10 minutes.Then all the fluid in the surgical site is suctioned as far as possible and at the end of the surgery the peritoneal air will be suctioned and the air in the posterior area of the liver is also actively suctioned. Intervention group 2: In the second group of patients, the Surgical Site Irrigation will done by 100 cc of 0.9% saline solution containing 0.5 mg / kg of ketamine for 5 to 10 minutes.Then all the fluid in the surgical site is suctioned as far as possible and at the end of the surgery the peritoneal air will be suctioned and the air in the posterior area of the liver is also actively suctioned. Control group: In the third group, the Surgical Site Irrigation will done by 100 ml of normal saline for 5 to 10 minutes.Then all the fluid in the surgical site is suctioned as far as possible and at the end of the surgery the peritoneal air will be suctioned and the air in the posterior area of the liver is also actively suctioned. Severity of Pain. Timepoint: Every 1 hour up to 24 hours after surgery. Method of measurement: VAS: Visual Analog Scale. Semnan University of Medical Sciences Approved 2016-10-01 Ethical Committee, Semnan University of Medical Sciences Basidj Boulevard Semnan Semnan Iran (Islamic Republic of)