IRCT20170926036425N1 IRCT 2018-09-17 National Nutrition and Food Technology Researc Institute Vitamin D and depression Evaluation of vitamin D supplementation effects on serum 25(OH)D3, PTH, pro-inflammatory biomarkers and neurotransmitters involved in depression, and depression status in depressive patients 2018-04-04 anticipated 60 Complete https://irct.ir/trial/29573 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: In this study, simple randomization method is used. Each person is given a random code when entering the study, and each person enters one of the two groups, depending on the received code, Blinding description: In this study, participants, clinical caregivers, researcher, outcome evaluator, data analyst, and data monitoring safety committee are kept blind and they are completely unaware of how to place specimens in the case or control group and of the consumption of supplement or placebo. Placebos used, apparently, will be quite similar to supplements. 0 (exploratory trials) depression. Intervention 1: Intervention group: Every two weeks receives 50000 IU vitamin D as vitamin D supplementation for 8 weeks, which is provided on a monthly basis. Intervention 2: Control group:Every two weeks receives a placebo apparently quite similar to vitamin D supplement, for 8 weeks, which is provided on a monthly basis. No - There is not a plan to make this available Justification or reason for not sharing IPD is In order to comply with medical ethics, the findings of this study will only be reported in groups.