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IRCT20180104038222N1 IRCT 2018-11-02 Yasouj University of Medical Sciences The effect of dexamethasone and methylprednisolone on post endodontic pain Comparison the effect of infiltration injection of dexamethasone and methylprednisolone on post endodontic pain in molars with necrosis pulp 2018-11-06 anticipated 80 Complete https://irct.ir/trial/29408 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple random allocation using random allocation software:The computer selects random numbers between 0 and 1. If the random number is <0.5, one goes to group A, and if the random number is> 0.5, then the individual goes to group B , Blinding description: Blindness is done using the medication sticker, and both the patient and the dentist do not know the medication content. 2-3 Post treatment endodontic pain. Intervention 1: Intervention group 1: Injection of 4 mg per cc dexamethasone in buccal vestibule after anesthetic injection. The drug is made in Iran and from the Alborz Pharmaceuticals Company with the chemical composition of C22H29FO5. The half-life of the drug is 36-54 hours. The severity of pain is recorded at 6, 12, 24, and 48 hours after treatment. Intervention 2: Intervention group 2: injection of 40 mg per cc of methylprednisolone in buccal vestibule after anesthetic injection. The drug is made in Iran and from Caspian Supply Company with chemical composition of C22H30O5. The half-life of the drug is 18-26 hours. The severity of pain is recorded at 6, 12, 24 and 48 hours after treatment. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is there is no more information
public Sheyda Yeganegi Asl
No. 8, 4th alley, Ayatollah Kashani Ave
Yasouj Iran (Islamic Republic of) 7591931873 +98 74 3322 8071 Mohammad.layegh@Yums.ac.ir Yasouj University of Medical Sciences scientific Sheyda Yeganegi Asl
No. 8, 4th alley, Ayatollah Kashani Ave
Yasouj Iran (Islamic Republic of) 7591931873 +98 74 3322 8071 Mohammad.layegh@yums.ac.ir Yasouj University of Medical Sciences Iran (Islamic Republic of) Required endodontic treatment in upper or lower molar teeth between 18 and 60 years of age Patients who are in healthy condition ASA 1 or 2 No periapical pathosis 18 years 60 years Both Patients who have received anti-inflammatory or analgesic drugs within last 8 hours Have a periodontal abscess or acute endodontic disease or any periodontal disease They need antibiotic prophylaxis Pregnant or lactating Have mental disabilities Have systemic disease which are contraindicated with endodontic treatment Have an acute infection Sensitivity to Dexamethasone and Methyl Prednisolone K08 Other specified disorders of teeth and supporting structures Treatment - Drugs Treatment - Drugs Intervention group 1: Injection of 4 mg per cc dexamethasone in buccal vestibule after anesthetic injection. The drug is made in Iran and from the Alborz Pharmaceuticals Company with the chemical composition of C22H29FO5. The half-life of the drug is 36-54 hours. The severity of pain is recorded at 6, 12, 24, and 48 hours after treatment. Intervention group 2: injection of 40 mg per cc of methylprednisolone in buccal vestibule after anesthetic injection. The drug is made in Iran and from Caspian Supply Company with chemical composition of C22H30O5. The half-life of the drug is 18-26 hours. The severity of pain is recorded at 6, 12, 24 and 48 hours after treatment Post treatment endodontic pain intensity. Timepoint: level of pain before root canal treatment and after 6,12, 24 and 48 hours. Method of measurement: Heft-parker visual analoug scale. Yasouj University of Medical Sciences Approved 2017-12-15 Ethics committee of Yasouj University of Medical Sciences Shahid Motahari blvd Yasouj Kohgilouyeh-va-Boyrahmad Iran (Islamic Republic of)