IRCT201411122999N4 IRCT 2015-07-10 Tabriz University Of Medical Science Effect of serteraline in depressed aggressive patients Description and comparison of autonomous nervous system function in aggressive depressed patients before and after serteralin treatment by the measurement of related biomarkers 2015-03-21 anticipated 50 Complete https://irct.ir/trial/2929 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment, Other design features: Present study is of "Before after study" type. 2-3 Depression. At first, the patients are scored by "Beck" 2nd edition questionnaire and "Structured Clinical Interview-DSM-IV (SCID) for severity of depression, and also by "State-Trait Anger Expression Inventory-2" questionnaire (STAXI-2) for the state of aggression. Afterwards, basic states of biomarkers, including heart rate, blood pressure, respiratory rate and etc... will be measured by a bio-feedback system. Then medical treatment with serteraline (Asentra, manufactured by ACTOVERCO factory, Karaj, Iran) by initial dose of 50 mg /day, orally, starts. The dosage could raise to 100 mg/day if weekly visits indicate that clinical response is inappropriate. At the intervals of 1.5 and 3 months later, autonomous biomarkers will be re-evaluted to compared with the basic states..