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IRCT20180111038311N1 IRCT 2018-04-03 Ahvaz University of Medical Sciences Efficacy of oralTranexamicAcid in melasma Comparison of efficacy of oralTranexamicAcid with4% topical hydroquinone in the treatment of melasma. 2017-08-23 anticipated 62 Complete https://irct.ir/trial/29044 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: According to the quadrilateral permutation blocks, patients are randomly divided into two groups. This treatment is administered to both groups for 3 months, Blinding description: As a record of the MASI score by a single person during the study, it does not have any information about the patient group being studied. During the treatment period, if the patient complains or does not want to continue treatment, the study will be discontinued. During the sampling process, we will evaluate the MASI score as a baseline at the start of treatment, and at the 4th week - 12th and 3 months after the end of treatment, as well as at the end of the 3-month treatment, the patient's satisfaction with the treatment will be recorded in each group. 3 Melasema. Intervention 1: Administration of the 250 mg Transxamic Acid Capsule Amin Pharmaceutical Company, Trancid capsule 250 milligram, is administered every 12 hours.On patients with melasma at the age of 18 to 60 years. Intervention 2: Control group: Administration of topical Hydroconjun 4% of Behzan Company, Iran (Cream Hydroquinone 4%), which is applied locally in the morning and night.On patients with melasma at the age of 18 to 60 years. Yes - There is a plan to make this available What will be shared: The total potential data can be shared after denationalization of people. When: Start the access period 1 year after the results print. To whom: Only available to scholars working in academia . Conditions: Only for statistical analysis or use in multi-center designs. Where to obtain: samin vala saminvala@gmail.com 009891633114629 How to obtain: Send request via academic email. we will Send the data file within one month from the time of request. Comments:
public Samin Vala
Eimam khomeini hospital, 24 metric Ave,Ahvaz
Ahvaz Iran (Islamic Republic of) 6193673111 +98 61322229223580 vala.s@ajums.ac.ir Ahvaz University of Medical Sciences scientific Reza Yaghoobi
Eimam khomeini hospital, 24 metric Ave,Ahvaz
Ahvaz Iran (Islamic Republic of) 6193673111 +98 61322229223580 Yaghoobi_rz@yahoo.com Ahvaz University of Medical Sciences Iran (Islamic Republic of) Patients with melasma with 18- 60 years old rang. 18 years 60 years Both Patients with coagulopathy Patients with thrombotic complications Any of thrombotic events Use of anticoagulant drugs or anti-platelet such as aspirin or Clopidogrel Pregnancy, lactation, concomitant use of contraceptives, The history of vitiligo or other pigmentation disorders, Trancexamic Acid Sensitivity History renal failure History of treatment for melasma with clarifying drugs in 3 months before the start of the study. L81.1 Chloasma Treatment - Drugs Treatment - Drugs Administration of the 250 mg Transxamic Acid Capsule Amin Pharmaceutical Company, Trancid capsule 250 milligram, is administered every 12 hours.On patients with melasma at the age of 18 to 60 years Control group: Administration of topical Hydroconjun 4% of Behzan Company, Iran (Cream Hydroquinone 4%), which is applied locally in the morning and night.On patients with melasma at the age of 18 to 60 years Pigmentation. Timepoint: MASIS record before intervention - one month and three months after intervention. Method of measurement: MASI Score. Gastrointestinal complications. Timepoint: before intervention - one month and three months after intervention. Method of measurement: Ask the patients. Hypomenorea. Timepoint: before intervention - one month and three months after intervention. Method of measurement: ASk the patients. Ahvaz University of Medical Sciences Approved 2017-08-23 Ethics committee of Ahvaz University of Medical Sciences ŮŽAhvaz Jundishapur University of Medical sciences, Daneshgahi town, Ahvaz Ahvaz Khouzestan Iran (Islamic Republic of)