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IRCT20150609022637N5 IRCT 2018-08-27 Kerman University of Medical Sciences Evaluation of effects of calcipotriol ointment on healing of skin graft donor site Evaluation of effects of calcipotriol ointment on healing of split thickness skin graft donor site: a single blind controlled trial 2018-06-22 anticipated 48 Complete https://irct.ir/trial/28990 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: The investigator who inspect the donor site regarding infection, bleeding and healing will be blinded in the following way: patient or one of his/her caregivers will apply the ointment every other day at morning. On the third day the donor site will be evaluated 4 to 6 hours after the ointment application, when the ointment has completely been absorbed and the intervention and control sites will not be different in this regard. The other times of the evaluation will be one day after the application of the ointment. ŮŽAgain the ointment has completely been absorbed and the intervention and control sites will not be different in this regard. Investigator who will statistically analyze data will not have any information about the source (intervention or control group) of data. Other investigators, patients and nurses will not be blinded. 3 Burn injury. Intervention 1: Intervention group: Calcipotriol ointment 0.005% (Tehran Shimi Company) will be applied topically on the donor site every other day for 10 days. Intervention 2: Control group: No intervention. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information.
public Naemeh Nikvarz
Pradis of Kerman University of Medical Sciences, Haft Bagh Road
Kerman Iran (Islamic Republic of) 7616911319 +98 34 3132 5017 nnikvarz@kmu.ac.ir Kerman University of Medical Sciences scientific Naemeh Nikvarz
Pardis of Kerman University of Medical Sciences, Haft bagh Road
Kerman Iran (Islamic Republic of) 7616911319 +98 34 3132 5017 nnikvarz@kmu.ac.ir Kerman University of Medical Sciences Iran (Islamic Republic of) Patients undergo split thickness skin graft Patients sign informed consent form 18 years no limit Both Infection of the donor site Bleeding of the donor site Pregnancy Lactation Hypercalcemia Hyperphosphatemia Renal failure Hepatic impairment Sepsis T30 Burn and corrosion, body region unspecified Treatment - Drugs N/A Intervention group: Calcipotriol ointment 0.005% (Tehran Shimi Company) will be applied topically on the donor site every other day for 10 days. Control group: No intervention Percent of epithelialization of the donor site. Timepoint: 10 days after the intervention. Method of measurement: Calculation of the ratio of the surface area of the epithelialized parts to the total surface area of the donor site. Number of episodes of the donor site infection. Timepoint: Before the intervention and 3, 6, 8 and 10 days after the intervention. Method of measurement: Inspection of the donor site and/or microbial culture of wound secretions. Number of episodes of the donor site bleeding. Timepoint: Before the intervention and 3, 6, 8 and 10 days after the intervention. Method of measurement: Inspection of the donor site. Kerman University of Medical Sciences Approved 2018-05-28 Ethics committee of Kerman University of Medical Sciences Office of the Vice Chancellor for Research, Ebne-sina Ave, Jahad Blvd Kerman Kerman Iran (Islamic Republic of)