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IRCT138810132967N1 IRCT 2010-02-27 Vice-chancellor for Research, Kashan University of Medical Sciences comparison of Letrozole and Clomiphene in combined regimens with gonadotropins in pregnancy rate in pcos patients with clomiphene resistant polycystic ovarian syndrome. comparison of Letrozole and Clomiphene in combined regimens with gonadotropins in pregnancy rate in pcos patients with clomiphene resistant polycystic ovarian syndrome. 2007-06-22 anticipated 120 Complete https://irct.ir/trial/2884 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Clomiphene resistant polycystic ovarian syndrome. Intervention 1: Letrozole 5mg (2 tablets) orally from 3-7 days of menstrual cycle in addition to gonadotropine (HMG) ampule 5th to 9th days of menstrual cycle which was continued on tenth or eleventh day of cycle after trasvaginal sonography, if needed. Intervention 2: Clomiphene 100mg (2 tablets) from 3-7 days of menstrual cycle in addition to gonadotropine (HMG) ampule 5th to 9th days of menstrual cycle which was continued on tenth or eleventh day of cycle after trasvaginal sonography, if needed.
public Dr. Fatemeh Foroozanfard
IVF Center, Shahid Beheshti HospitaL, Ghotbe Ravandi Blvd.
Kashan Iran (Islamic Republic of) +98 36 1542 1355 forozanfar_f@kaums.ac.irfatemehforoozanfard@yahoo.com Kashan University of Medical Sciences scientific Dr.Fatemeh Foroozanfard
IVF Center, Shahid Beheshti HospitaL, Ghotbe Ravandi Blvd.
Kashan Iran (Islamic Republic of) +98 36 1542 1355 forozanfar_f@kaums.ac.ir fatemehforoozanfard@yahoo.com Kashan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Clomiphene resistant polycystic ovarian syndrome, age 20-35 years Exclusion criteria: BMI more than 27, presence of hypothyroidism, hyperprolactinemia, or decreased ovarian reserve, male factor infertility, tubal or uterine factor diagnosed by HSG, peritoneal factor (history of previous surgery) 20 years 35 years Female N80 Noninflammatory disorders of female genital tract Treatment - Drugs Treatment - Drugs Letrozole 5mg (2 tablets) orally from 3-7 days of menstrual cycle in addition to gonadotropine (HMG) ampule 5th to 9th days of menstrual cycle which was continued on tenth or eleventh day of cycle after trasvaginal sonography, if needed Clomiphene 100mg (2 tablets) from 3-7 days of menstrual cycle in addition to gonadotropine (HMG) ampule 5th to 9th days of menstrual cycle which was continued on tenth or eleventh day of cycle after trasvaginal sonography, if needed Endometrial thickness. Timepoint: Tenth or eleventh day of menstrual cycle. Method of measurement: Transvaginal sonography. Ovarian response. Timepoint: Tenth or eleventh of menstrual cycle. Method of measurement: Transvaginal sonography. Gonadotropin ampule consuption. Timepoint: Tenth or eleventh of menstrual cycle. Method of measurement: Transvaginal sonography. Pregnancy rate. Timepoint: Two weeks after HCG injection. Method of measurement: pregnancy test. Vice-chancellor for Research, Kashan University of Medical Sciences Approved 2007-06-09 Kashan University of Medical Sciences Vice-chancellor for Research, Ghotbe Ravandi Blvd, Kashan Kashan Iran (Islamic Republic of)