IRCT20171216037889N1 IRCT 2018-01-22 Iran University of Medical Sciences Cinnamomum tamala in the treatment of major depression Evaluation of the efficacy of oral administration of Cinnamomum tamala with placebo in patients with depressive disorder 2018-01-29 anticipated 50 Complete https://irct.ir/trial/28352 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are randomly assigned to intervention and control groups based on simple randomization method, Blinding description: Patients are randomly divided into two groups and receive drug box with the same shape and size but different content,each patient is advised to take an oral capsule daily,the patient, the physician who will examine the patients and appraiser of them will not be aware of the contents of the drug containers. 3 Depression. Intervention 1: Intervention group: cinnamomum tamala 250-500 mg daily plus sertraline 50-100 mg / day. Intervention 2: Control group: Placebo 250-500 mg daily with sertraline 50-100 mg / day. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information