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IRCT201509042946N7 IRCT 2016-12-07 Vice chancellor for reasearch ,Kermanshah University of Medical Sciences comparison of headache accurance and severity after use of phenylephtine and ephedrine for treatment of hypotention during cesarian delivery under spinal anesthesia Comparison of headache prevalence and intensity following administration of ephedrine and phenylephrine in cesarean section under spinal anesthesia 2016-08-21 anticipated 105 Complete https://irct.ir/trial/2827 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Other design features: Drug prepration will done by an anesthetic nurse. Drug prescription will done by second and evaluation of accurance and severity of headache will done by third nurse. All of nurses and patientswill blinded with type of vasopressor. Randomization will done in allocation of patients to two drug groups(phenylephrine and ephedrine). 2-3 headache. Intervention 1: Ephedrine ampule 10 mcgr, Intravenous, repeated until hemodynamic stability. Intervention 2: Phenylephrine ampule 50 mcgr, Intravenous, repeated until hemodynamic stability in the first case group.
public Dr. Mitra Yari
Imam Reza Hospital, Parastar boulevard, Sorkhalijeh
kermanshah Iran (Islamic Republic of) 67144-15333 +98 83 3433 4157 myari@kums.ac.ir Kermanshah University of Medical Sciences scientific Dr. Mitra Yari
Kermanshah University of Medical Sciences
kermanshah Iran (Islamic Republic of) 00988337253775 +98 83 3427 6310 myari@kums.ac.ir Kermanshah University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Pregnant women aged 18 to 40 years; ASA class I_II; systolic blood pressure 120-140 mmhg; body mass index 18.5_25 and normal single fetus pregnancy. Exclusion criteria: History of migraine; psychiatric disorders; any medication except pregnancy supplements; presence of headache in admission time to operation room; eclampsia; preeclampsia; hypertention; diabetes mellitus and cardiovascular disease. 18 years 40 years Female G44.4 Drug-induced headache, not elsewhere classified Prevention Prevention Ephedrine ampule 10 mcgr, Intravenous, repeated until hemodynamic stability Phenylephrine ampule 50 mcgr, Intravenous, repeated until hemodynamic stability in the first case group Headache incidence and intencity. Timepoint: during cesarean, 1, 6, 24 hours later. Method of measurement: by visual analogue scale. Vital sign changes. Timepoint: every 2 minute until 10minute then every 5 minute. Method of measurement: by datascope monitor. Vice chancellor for reasearch ,Kermanshah University of Medical Sciences Approved 2015-08-18 ethics committee of Kermanshah University of Medical Sciences No. 2 building of Medical University, Shahid Beheshti boulevard kermanshah Iran (Islamic Republic of)