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IRCT20130310012776N4 IRCT 2018-08-02 Shiraz University of Medical Sciences effect of Propranolol in Traumatic Brain Injury (TBI) Evaluation of the effect of Propranolol on the Prognosis of Traumatic Brain Injury (TBI) 2017-12-06 anticipated 110 Complete https://irct.ir/trial/28119 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: simple randomization with randomizer software, Blinding description: ICU patients and attending Physician are unaware of treatment group. 3 TBI. Intervention 1: Intervention group: 20 mg propranolol every 8 hours for 10 days. Intervention 2: control group: no drug use. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Due to the fact that the results are still unclear and there is no specific protocol for the use of this drug, the selection of the appropriate source for the publication of the results is not possible at this time. if the medicine is effective, its specific resources are selected after determining the results.
public Hosseinali Khalili
Rajaee Hospital, Chamran Blvd
Shiraz Iran (Islamic Republic of) 7194815711 +98 71 3624 8980 khalili_h@sums.ac.ir Shiraz University of Medical Sciences scientific Hossein Ali Khalili
Rajaee Hospital, Chamran Blvd
Shiraz Iran (Islamic Republic of) 7194815711 +98 71 1623 4508 khalili_h@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) age >18 years blunt brain injury mechanism admission to neurosurgical intensive care unit (NICU) 16 years no limit Both patients were prescribed regular beta-blocker therapy pre-admission those suffering any extracranial injuries requiring invasive interventions or surgery S06.2 Diffuse traumatic brain injury Treatment - Drugs Placebo Intervention group: 20 mg propranolol every 8 hours for 10 days. control group: no drug use Glasgow Outcome Score Extended (GOS-E). Timepoint: 6 months. Method of measurement: clinical exam. Shiraz University of Medical Sciences Approved 2017-11-05 Ethics committee of Shiraz University of Medical Sciences 6th Floor,Central building of Shiraz University of Medical Sciences, Zand St Shiraz Fars Iran (Islamic Republic of)