IRCT20140519017756N36 IRCT 2018-01-31 Birjand University of Medical Sciences The effects of three anesthetics on the amount of intraoperative bleeding Comparing the effects of clonidine, morphine and promethazine as pre-medication on intraoperative bleeding and hemodynamic stability of patients during septorhinoplasty surgeries 2017-06-08 anticipated 60 Complete https://irct.ir/trial/28039 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Allocation is via table of random numbers, Blinding description: Firstly, the participants are blind to the pre-medication they are to receive. Although they are explained about the study design and procedure, they are not informed of the type of medication they will receive, especially because the medications are already established as standard drugs. Moreover, on-site evaluators and statistical analysts are not aware of the study groups. 2 intraoperative bleeding. Intervention 1: Intervention group (morphine): Receiving 0.1 milligram/kilogram body weight of morphine intramuscularly an hour before surgery. Intervention 2: Intervention group (Promethazine): 25 milligrams of promethazine (syrup or tablet) an hour before surgery. Intervention 3: Intervention group (clonidine): 300 micrograms of clonidine tablets an hour before surgery. No - There is not a plan to make this available Justification or reason for not sharing IPD is The majority of participants agreed to participate if the confidentiality of data would be guaranteed, given the type of surgery they would undergo.