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IRCT20171129037677N1 IRCT 2018-04-27 Mashhad University of Medical Sciences The effect of levothyroxine in subclinical hypothyroidism SCH The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism 2017-09-23 anticipated 30 Complete https://irct.ir/trial/27929 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: In this work, using a simple randomization model (computer randomization method), we will rank each referral in the intervention or control group based on the order of the randomization table. Statistical software is a random tool. The randomization unit is individual. Levothyroxine and placebo will be placed in the numbered envelopes, each patient will be given an open envelope at the clinic and given the medicine, Blinding description: Based on the randomization table that will be provided by the computer, levothyroxine and placebo will be placed in the numbered envelopes; each patient will be given an open envelope for each patient and the medication will be given to him. A list of how the patient is assigned to one of the project partners to inform him about the grouping of patients. The patient will not be aware of the grouping. During this 60 day period (treatment period), at least 1 time a month, contact persons are contacted to ensure that patients are taking drugs. Patients are also asked to do the test again at week eight after starting treatment. 3 Subclinical hypothyroidism. Intervention group: Levothyroxine receptor. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is no information
public Masoud Mohebbi
Central Building of Mashhad University of Medical Sciences (Ghorshi), Daneshgah 16, Daneshgah street
Mashhad Iran (Islamic Republic of) 9177899191 +98 51 3802 2358 MohebbiM@mums.ac.ir Mashhad University of Medical Sciences scientific Masoud Mohebbi
Emam Reza hospital
Mashhad Iran (Islamic Republic of) 91379-13131 +98 518413006 mohebbim@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) People aged 20-40 years old referred to the endocrinology clinic Subclinical hypothyroidism have indications of treatment(Tsh5-15 andT3-T4 in normal range) 20 years 40 years Both History of hypothyroidism Treated with antithyroid drugs Metabolic bone disorder Hypoparathyroid and hyperparathyroid Acromegaly Drugs that cause thyroid dysfunction: Interferon-tyrosine kinase-cortisone and ocp Drugs that affect insulin levels E02 Subclinical iodine-deficiency hypothyroidism Treatment - Drugs Intervention group: Levothyroxine receptor Serum osteocalcin levels. Timepoint: Measurement of osteocalcin levels before the intervention and two months later. Method of measurement: Serum level evaluation. Mashhad University of Medical Sciences Approved 2017-09-27 Ethics committee of Mashhad University of Medical Sciences Emam Reza hospital.Bahar street Mashhad Razavi Khorasan Iran (Islamic Republic of)