IRCT20140413017254N5 IRCT 2017-12-28 Tehran University of Medical Sciences Effect of Nano curcumin on the severity of diabetic sensorimotor polyneuropathy Effect of Nano curcumin supplementation on the severity of diabetic sensorimotor polyneuropathy in type 2 diabetic patients : a double- blind randomized clinical trial 2018-01-21 anticipated 80 Complete https://irct.ir/trial/27878 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: For random allocation of individuals by statistic expert, permute-block randomization will be used for the two groups of study; thus, four blocks of AABB, ABAB, ABBA, BBAA, BABA, and BAAB are selected 20 times randomly and with placement, and The letters of the selected blocks will be written after each other. Stratified randomization will be used to control age and gender variables, based on the following categories: age (30-45, 46-60) and gender (male, female), Blinding description: The researcher and the patient do not have any information on the type of supplement that they receive and they are prepared in the same way as in the form of tablets and supplements like nano-curcumin. A person who is not aware of the packet content will be asked to complete the naming of the supplement and the placebo in groups A and B. After collecting data at the end of the study, the codes of supplements will be specified for the researchers. 3 Diadetic polyneuropathy. Intervention 1: Intervention group: Supplement that made of nano mucosal curcumin, an effective ingredient in turmeric, is prepared in the form of gelatin capsules of 80 milligrams from the Minoo Pharmaceutical Company. A 80 mg supplement will be consumed daily as a lunch capsule. Intervention 2: Control group: Placebo, which consists of all drug formulation components except the effective curcumin agent, is prepared in the form of gel capsules of 80 mg from Minoo Pharmaceutical Company. A 80 mg supplement will be consumed daily as a lunch capsule. Undecided - It is not yet known if there will be a plan to make this available