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IRCT20141209020258N61 IRCT 2018-01-09 Arak University of Medical Sciences Comparison effect of Apotel and Pergabalin in reduce pain after ‎in orthopedic surgery ‎ Comparison effect of Apotel and Pergabalin in reduce pain after ‎in orthopedic surgery ‎ 2017-08-23 anticipated 75 Complete https://irct.ir/trial/27840 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random numbers table, Blinding description: The study is double-blind. The participant and the outcome evaluator are unaware. blindness in control group,we give normal saline in serum and capsule of placebo.blindness in intervention group, we give apotel in serum and capsule of placebo.blindness in another intervention group normal saline in serum and tab of Pregabalin. In this way, patients are not informed of the group they are in. 2-3 pain after surgery. Intervention 1: Intervention group: We treat patients 150 miligeram pregabalin 2 hours before surgery in intervention group.‎. Intervention 2: Intervention group: We treat patients 1 gram Apotel in 200 milliliter 20 minute before surgery in intervention group.‎. Intervention 3: Control group: We treat patients one capsule placebo before surgery in intervention group.‎. Yes - There is a plan to make this available What will be shared: When we publish article in journal. When: After the article is published To whom: researcher in university Conditions: If there are additional questions Where to obtain: Dr Mehran Azami How to obtain: They have to write letters to the professors and the university Comments:
public Dr Alireza Kamali
Valiasr Hospital, Valiasr square, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 alikamaliir@yahoo.com Arak University of Medical Sciences scientific Dr Mehran Azami
Valiasr Hospital, Valiasr square, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 mazami@arakmu.ac.ir Arak University of Medical Sciences Iran (Islamic Republic of) candidate orthopedic surgery ‎lower limb 17 to 65 years both of two gender 17 years 65 years Both Coagulation disorders Unwillingness to participate in the study Severe hemodynamic instability Hepatic, renal and cardiac disease Sensitivity to Pregabalin and Apotel G89 Pain, not elsewhere classified Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: We treat patients 150 miligeram pregabalin 2 hours before surgery in intervention group.‎ Intervention group: We treat patients 1 gram Apotel in 200 milliliter 20 minute before surgery in intervention group.‎ Control group: We treat patients one capsule placebo before surgery in intervention group.‎ Pain. Timepoint: We record pain in recovery, 2 and 12 and 24 hours after surgery. Method of measurement: Visual Analog Sacle. Consumption of opioids. Timepoint: We record consumption of opioids in 24 hours in milligram. Method of measurement: milligram. Sedation. Timepoint: We record ramsy sedation score in 24 hours after surgery.‎. Method of measurement: ramsy sedation score. Arak University of Medical Sciences Approved 2017-08-14 Ethics committee Arak University Of Medical Sciences Vice chancellor for research, Payambar azam complex, Basij squre, Sardasht, Arak Arak Markazi Iran (Islamic Republic of)