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IRCT20171126037629N1 IRCT 2018-01-02 Qazvin University of Medical Sciences Evaluation the effect of prophylactic administration of antibiotics in decreasing of wound infection in patients candidates laparoscopic cholecystectomy Evaluation the effect of prophylactic administration of first-generation cephalosporin antibiotics in decreasing of wound infection in patients candidates laparoscopic cholecystectomy 2017-11-22 anticipated 268 Complete https://irct.ir/trial/27838 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Study is done as randomized, double blind on the individual by closed packet, Blinding description: Study is done as randomized, double blind (investigator and patients) by closed packet ( by assigning the letters A and B to the cards in the envelope and randomly selecting the envelopes by the patients). Before study informed consent form are completed by patients. 2 gallbladder. Intervention 1: Intervention group: 25 mg/kg cefazolin in per intervenes injection before surgery and 2 dose per 8 hours after surgery. Intervention 2: Control group: Without drug regimen. No - There is not a plan to make this available Justification or reason for not sharing IPD is That is secret according to informed consent.
public Reza Noori Moghadam
Shahid Bahonar Blvd.
Qazvin Iran (Islamic Republic of) 34139-96134 +98 28 3333 5800 rajresearch95@gmail.com Qazvin University of Medical Sciences scientific Davood Mohammadi
Shahid Bahonar Blvd.
Qazvin Iran (Islamic Republic of) 34139-96134 +98 28 3333 5800 rajresearch95@gmail.com Qazvin University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: patients candidate laparoscopic cholecystectomy; age<60. no limit 60 years Both Exclusion criteria: consumption antibiotic in 7 days ago cholecyst in 6 past months Evidence of colaenitis or obstructive jaundice and biliary pancreatitis systematic Corticosteroid therapy reduced kidney function and liver failure history of allergy disorder in PT and PTT drug interactions with cephalosporin Breast feeding or pregnancy History of biliary tract surgery or endoscopic retrograded cholangiography previous. K80.1 Calculus of gallbladder with other cholecystitis Treatment - Drugs Treatment - Drugs Intervention group: 25 mg/kg cefazolin in per intervenes injection before surgery and 2 dose per 8 hours after surgery Control group: Without drug regimen. Post operative pain. Timepoint: The pain is assessed at 24, 48 and 72 hours after surgery. Method of measurement: The visual analogous scale. Qazvin University of Medical Sciences Approved 2017-10-25 Ethical committee of Qazvin university of medical sciences Shahid Bahonar Blvd. Qazvin Qazvin Iran (Islamic Republic of)