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IRCT20171115037478N1 IRCT 2018-02-07 Zanjan University of Medical Sciences Fluoxetine Therapeutic Effects With Duloxetine in patients with IBS with constipation Comparison of Fluoxetine Therapeutic Effects With Duloxetine in patients with IBS with constipation 2017-11-21 anticipated 120 Complete https://irct.ir/trial/27797 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The method of selecting individuals and their placement in triple groups will be randomized, so that after confirmation of the conditions necessary for inclusion in the study patients will be selected sequentially and the first patient in the first group, the second patient in The second group and the third patient will be placed in the third group, and in the same way, again, the groups will take each patient in order to reach the desired level. 3 Irritable bowel syndrome is a type of constipation. Intervention 1: Intervention group1: The first group of dicyclomin tablets is given every 8 hours with fluoxetine 20 mg daily for 2 months. Intervention 2: Intervention group 2: The second group of dicyclomine tablets is given every 8 hours with duloxetine 20 mg daily for 2 months. Intervention 3: Intervention group 3: The third group of dicyclomine tablets is given every 8 hours 20 mg daily for 2 months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is it doesn't change the course of research if the personal IDs don't be clarified.
public Behnam sajedi
Shariati St., Valiasr Hospital
Zanjan Iran (Islamic Republic of) 4515777978 +98 24 3377 0801 Behnamsajedi1365@zums.ac.ir Zanjan University of Medical Sciences scientific Behnam Sajedi
Shariati St., Valiasr Hospital
Zanjan Iran (Islamic Republic of) 4515777978 +98 24 3377 0801 Behnamsajedi1365@zums.ac.ir Zanjan University of Medical Sciences Iran (Islamic Republic of) new cases of irritable bowel syndrome aged 18-45 constipation predominant symptoms consistent with the criteria Rome2 criteria 18 years 45 years Both patients with night diarrhea patients with weight loss patients with history of GI bleeding patients that use alcohol, drugs and opiums. patients with psychological diseases patients with CNS disorders patients with kidney or liver failure cardica patients K58 Irritable bowel syndrome Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group1: The first group of dicyclomin tablets is given every 8 hours with fluoxetine 20 mg daily for 2 months Intervention group 2: The second group of dicyclomine tablets is given every 8 hours with duloxetine 20 mg daily for 2 months. Intervention group 3: The third group of dicyclomine tablets is given every 8 hours 20 mg daily for 2 months. Severity of illness in irritable bowel syndrome, constipation type. Timepoint: At the beginning of the study and two months later. Method of measurement: IBS-SSS(IBS-(Severity scoring system). Zanjan University of Medical Sciences Approved 2017-08-07 Zanjan University of Medical Sciences Ethics Committee Khorramshahr Street Zanjan Zanjan Iran (Islamic Republic of)