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IRCT20171122037584N1 IRCT 2018-01-07 Hamedan University of Medical Sciences Investigation the effect of herbal supplement on lead concentration Investigation the effect of Silymarin on reducing lead blood concentration and oxidative stress biomarkers in opioid addicts. 2018-02-20 anticipated 60 Complete https://irct.ir/trial/27793 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization In this study, a simple random lottery method will be used. In this method all units or individuals listed or their names are provided. And then they will be divided into two groups by lot, Blinding description: Participants are blind (placebo or treatment). N/A lead poisoning. Intervention 1: Intervention group: In this study, the intervention group included the active ingredient of silymarin in the form of a Livergol produced by Gol-Daru Company receives 420 mg daily (three times every 140 mg) for three months. Intervention 2: Control group: A group that receives a pill similar to Livergel as a placebo. Yes - There is a plan to make this available What will be shared: The whole data of individuals unidentifiablely When: After publication the article, results will be available To whom: Data is available to the public after being publicized. Conditions: For further studies Where to obtain: m.mohammadi@umsha.ac.ir How to obtain: Sending email is enough Comments:
public Mojdeh Mohammadi
Hamadan university of medical sciences, Shaheed Fahmideh Blvd
Hamadan Iran (Islamic Republic of) 6517838678 +98 912 610 0687 m.mohanmmadi@umsha.ac.ir Hamedan University of Medical Sciences scientific Mojdeh Mohammadi
Hamadan unirsity of medical sciences, Shaheed Fahmideh Blvd
Hamadan Iran (Islamic Republic of) 6517838678 +98 912 610 0687 m.mohammadi@umsha.ac.ir Hamedan University of Medical Sciences Iran (Islamic Republic of) 18-60 years old blood lead level>10mcg/dl opium abuser 18 years 60 years Both Age under 18 years Get other types of other antioxidants Gastrointestinal diseases, especially absorption disorders, which can affect the effective absorption of the drug History of heart, kidney, and liver disease R78.71 Abnormal lead level in blood Treatment - Drugs Placebo Intervention group: In this study, the intervention group included the active ingredient of silymarin in the form of a Livergol produced by Gol-Daru Company receives 420 mg daily (three times every 140 mg) for three months. Control group: A group that receives a pill similar to Livergel as a placebo. Blood lead level. Timepoint: Blood lead level measurement before drug interventions and And three months after use of the medication. Method of measurement: Atomic absorption. Hamedan University of Medical Sciences Approved 2017-11-04 Ethics Committee of Hamadan University of Medical Sciences Hamadan university of medical sciences, Shaheed Fahmideh Blvd, Hamadan, Iran Hamadan Hamadan Iran (Islamic Republic of)