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IRCT20170902036032N1 IRCT 2018-02-25 Shahroud University of Medical Sciences Compare the effect of ondansetron and Dexamethasone with metoclopramide and Dexamethasone in the control of nausea and vomiting after chemotherapy Compare the effect of ondansetron and Dexamethasone with metoclopramide and Dexamethasone in the control of nausea and vomiting after chemotherapy in cancer patients referred to Imam Hossein hospitals of Shahroud on 2017, a randomized double blind clinical trial 2017-12-22 anticipated 86 Complete https://irct.ir/trial/27782 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: The randomization method is simple, Individual randomization unit Using random quadrants blocks, Blinding description: The study is a double blind clinical trial in which the participants, the main researcher, the data collection authorities and those who evaluate the outcome. 4 Under chemotherapy. Intervention 1: Intervention group: Ondonestrone 0 / 1mg / kg with 2 cc normal saline plus 8 mg dexamethasone intravenously. Intervention 2: Control group: Metoclopramide 0.15 mg / kg plus 8 mg dexamethasone intravenously. Undecided - It is not yet known if there will be a plan to make this available
public Mehrshad Mousapour
Shahroud University of Medical Sciences and Health Services,Hafte-Tir Square,Shahroud
Shahroud Iran (Islamic Republic of) 1648813879 +98 21 7792 6610 mousapour@shmu.ac.ir Shahroud University of Medical Sciences scientific Mehrshad Mousapour
Shahroud University of Medical Sciences and Health Services,Hafte-Tir Square,Shahroud
Shahroud Iran (Islamic Republic of) 1648813879 +98 21 7792 6610 mousapour@shmu.ac.ir Shahroud University of Medical Sciences Iran (Islamic Republic of) A definitive diagnosis of a cancer that needs chemotherapy There is no other systemic disease (such as obstructive bowel disease and gastroenteritis, central nervous system problems, and equilibrium problems) Have a previous history of chemotherapy at least three times Age range 15 to 65 years Fear and complain about severe and fairly intense nausea and vomiting in previous chemotherapy No use oral antinausea or injection medicines in the last 7 days Desire and satisfaction to enter the study 15 years 65 years Both Use an anti-nausea and vomiting medicine for at least the past 7 days Dissatisfaction with this treatment Those who use drugs There is a severe allergic reaction to either of the two drugs, Endonestrone and Metoclopramide Dissatisfaction with cooperation and participation in the project Z51.11 Encounter for antineoplastic chemotherapy Treatment - Drugs Treatment - Drugs Intervention group: Ondonestrone 0 / 1mg / kg with 2 cc normal saline plus 8 mg dexamethasone intravenously Control group: Metoclopramide 0.15 mg / kg plus 8 mg dexamethasone intravenously Severity of pain. Timepoint: After treatment. Method of measurement: Visual Scale. Nausea and vomiting. Timepoint: After treatment. Method of measurement: Visual Scale. Complication after treatment of two drugs. Timepoint: After treatment. Method of measurement: Visual Scale. Severe nausea after treatment. Timepoint: After treatment. Method of measurement: Visual Scale. Shahroud University of Medical Sciences Approved 2016-11-09 Ethics Committee of Shahroud University of Medical Sciences shahroud University of Medical Sciences and Health Services,Hafte-Tir Square,Shahroud Shahroud Semnan Iran (Islamic Republic of)