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IRCT20171113037432N1 IRCT 2018-01-02 EMG-NCV institution of khatam alanba clinic The effect of corticosteroid injection in carpal tunnel syndrom The Effect of intraoperative local Dexamethasone injection in carpal tunnel release on symptoms and EMG-NCV. 2017-02-18 anticipated 50 Complete https://irct.ir/trial/27699 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: none, Randomization description: randomization was based on a computer randomized number chart. each patient was granted a randomized number due to order of referral. the number specifies which group it belongs to, Blinding description: This is a double-blinded design study.the patient and the center taking the EMG-NCV records and the colleague gathering the information of the questionnarie from patients are blinded to which patient belongs to which group. N/A Carpal tunnel syndrome. Intervention 1: Control group : The surgery begins with a 4cm volar skin incision starting from distal to the distal wrist crease in line with the third web space. then transverse carpal ligament and 2cm of distal antebrachial fascia is completely incised and the median nerve is released, the median nerve and the tunnel are explored for possible pathologies, the wound is irrigated and skin is closed. Intervention 2: Intervention group : The surgery begins with a 4cm volar incision starting from distal to the distal wrist crease in line with the third web space. then transverse carpal ligament and 2cm of distal antebrachial fascia is completely incised and the median nerve is released, the median nerve and the tunnel are explored for possible pathologies and the wound is irrigated in this step 1ml of dexamethasone with 4 mili-gram in one mili-liter concentration is injected in the flexor tendon sheath and in borders of the transverse ligament cuts and spilled around the median nerve, the difference between two study groups is just in this step and other surgical steps are the same for both groups. then the skin is closed. Undecided - It is not yet known if there will be a plan to make this available
public dr. mostafa zare mehrjardi
yazd bahonar square
yazd Iran (Islamic Republic of) 8915173149 +353 8203410 m.zaremehrjardi@ssu.ac.ir shahid sadooghi univercity of medical siences scientific dr. mostafa zare mehrjardi
Bahonar square, Yazd
yazd Iran (Islamic Republic of) 8915173149 +353 8202632 m.zaremehrjardi@ssu.ac.ir shahid sadooghi univercity of medical siences Iran (Islamic Republic of) Iran (Islamic Republic of) Iran (Islamic Republic of) Patients who come to Yazd's Shahid Rahnemoon clinic, Khatam Alanbia clinic and Baghaiee poor clinic who are suspected to have carpal tunnel syndrome by symptoms. then they are diagnosed by delay in distal motor reaction by 4.5 ms and sensory nerve conduction velocity of more than 3.5 ms in EMG-NCV. Age of less than 65 and more than 25 Doesn't have known autoimmune or collagen vascular disease Symptoms of no more than 2 years No history of recent systemic corticosteroid consumption 25 years 65 years Both median nerve pathologic condition encountered during surgery G56.0 Carpal tunnel syndrome Treatment - Surgery Treatment - Surgery Control group : The surgery begins with a 4cm volar skin incision starting from distal to the distal wrist crease in line with the third web space. then transverse carpal ligament and 2cm of distal antebrachial fascia is completely incised and the median nerve is released, the median nerve and the tunnel are explored for possible pathologies, the wound is irrigated and skin is closed. Intervention group : The surgery begins with a 4cm volar incision starting from distal to the distal wrist crease in line with the third web space. then transverse carpal ligament and 2cm of distal antebrachial fascia is completely incised and the median nerve is released, the median nerve and the tunnel are explored for possible pathologies and the wound is irrigated in this step 1ml of dexamethasone with 4 mili-gram in one mili-liter concentration is injected in the flexor tendon sheath and in borders of the transverse ligament cuts and spilled around the median nerve, the difference between two study groups is just in this step and other surgical steps are the same for both groups. then the skin is closed. Improvement in symptoms. Timepoint: just before surgery and 2 weeks after surgery. Method of measurement: questionnarie value is the sum of nembers given to each symptom and is a integer. EMG-NCV records for median nerve. Timepoint: first in one month before surgery and second time 3 month after surgery. Method of measurement: the time that impulse pass through nerve and is measured by milli-seconds. EMG-NCV institution of khatam alanba clinic Approved 2017-10-04 Ethics committee of shahid sadooghi university of medical sciences of yazd yazd, alam square yazd Yazd Iran (Islamic Republic of)