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IRCT20171112037420N1 IRCT 2018-01-03 Sabzevar University of Medical Sciences Comparison of Levofloxacin based quadruple therapy with standard treatment in eradication of helicobacter pylori as first line Therapy Comparison of Levofloxacin-containing quadruple therapy versus standard triple therapy as the first line for the helicobacter pylori eradication 2017-06-13 anticipated 98 Complete https://irct.ir/trial/27691 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Helicobacter Pylori infection. Intervention 1: Control group: Levofloxacin-containing quadruple therapy (Levofloxacin 500 mg bid, Bismuth 240 mg qid, Amoxicillin 1 gr bid and Pantoprazole 40 mg bid) for 2 weeks. Intervention 2: Intervention group: standard triple therapy (Clarithromycin 500 mg bid, Amoxicillin 1 gr bid, Pantoprazole 40 mg bid) for 2 weeks. Undecided - It is not yet known if there will be a plan to make this available
public M.s Salehe Eydi
Central Organization of Medical Sciences, Asad Abadi Street, sabzevar
Sabzevar Iran (Islamic Republic of) 9613873136 +98 51 4401 1000 info@medsab.ac.ir Sabzevar University of Medical Sciences scientific Dr. Mehdi Molavi
Central Organization of Medical Sciences, Asad Abadi Street, Sabzevar
Sabzevar Iran (Islamic Republic of) 9613873136 +98 51 4401 1000 info@medsab.ac.ir Sabzevar University of Medical Sciences Iran (Islamic Republic of) Patients who are performed upper endoscopy and have positive rapid urease test. Patients with over 18 years of age 18 years no limit Both Pregnancy Allergy to medicent which used this study Patients were treated helicobacter pylori eradication previously. lack of willingness to continue the period of treatment lack of willingness to complete the period of treatment B98.0 Helicobacter pylori [H.pylori] as the cause of diseases classified to other chapters Treatment - Drugs Treatment - Drugs Control group: Levofloxacin-containing quadruple therapy (Levofloxacin 500 mg bid, Bismuth 240 mg qid, Amoxicillin 1 gr bid and Pantoprazole 40 mg bid) for 2 weeks Intervention group: standard triple therapy (Clarithromycin 500 mg bid, Amoxicillin 1 gr bid, Pantoprazole 40 mg bid) for 2 weeks Eradication of Helicobacter Pylori infection. Timepoint: 3 weeks after the completion of treatment. Method of measurement: Helicobacter pylori stool antigen test. Diarrhea. Timepoint: During the period of treatment. Method of measurement: Questionnaire. Nausea. Timepoint: During the period of treatment. Method of measurement: Questionnaire. Headache. Timepoint: During the period of treatment. Method of measurement: Questionnaire. Hiccups. Timepoint: During the period of treatment. Method of measurement: Questionnaire. Skin rash. Timepoint: During the period of treatment. Method of measurement: Questionnaire. Papilation. Timepoint: During the period of treatment. Method of measurement: Questionnaire. Bitter taste. Timepoint: During the period of treatment. Method of measurement: Questionnaire. Neuropathic pain. Timepoint: During the period of treatment. Method of measurement: Questionnaire. Constipation. Timepoint: During the period of treatment. Method of measurement: Questionnaire. Chest stress. Timepoint: During the period of treatment. Method of measurement: Questionnaire. Vometting. Timepoint: During the period of treatment. Method of measurement: Questionnaire. Vice chancellor for research, Sabzevar University of Medical Sciences Approved 2017-06-12 Ethics Committee of Sabzevar University of Medical Sciences and Health Services Central Organization of Medical Sciences, Asad Abadi Street, sabzevar sabzevar Razavi Khorasan Iran (Islamic Republic of)